Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer. A loss of ATM is also associated with increased protein aggregation. The relevance and characterist...

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Detalles Bibliográficos
Autores principales: Huiting, Wouter, Dekker, Suzanne L, van der Lienden, Joris CJ, Mergener, Rafaella, Musskopf, Maiara K, Furtado, Gabriel V, Gerrits, Emma, Coit, David, Oghbaie, Mehrnoosh, Di Stefano, Luciano H, Schepers, Hein, van Waarde-Verhagen, Maria AWH, Couzijn, Suzanne, Barazzuol, Lara, LaCava, John, Kampinga, Harm H, Bergink, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871389/
https://www.ncbi.nlm.nih.gov/pubmed/35200138
http://dx.doi.org/10.7554/eLife.70726

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