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Diagnostic Value of Interferon-Gamma Release Assays for Tuberculosis in the Immunocompromised Population
Interferon-gamma release assays (IGRAs) are widely used in the diagnosis of Mycobacterium tuberculosis (M. tuberculosis) infection by detecting interferon-γ released by previously sensitized T-cells in-vitro. Currently, there are two assays based on either enzyme-linked immunosorbent assay (ELISA) o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871457/ https://www.ncbi.nlm.nih.gov/pubmed/35204544 http://dx.doi.org/10.3390/diagnostics12020453 |
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author | Yang, Ying Wang, Hong-Jiao Hu, Wei-Lin Bai, Guan-Nan Hua, Chun-Zhen |
author_facet | Yang, Ying Wang, Hong-Jiao Hu, Wei-Lin Bai, Guan-Nan Hua, Chun-Zhen |
author_sort | Yang, Ying |
collection | PubMed |
description | Interferon-gamma release assays (IGRAs) are widely used in the diagnosis of Mycobacterium tuberculosis (M. tuberculosis) infection by detecting interferon-γ released by previously sensitized T-cells in-vitro. Currently, there are two assays based on either enzyme-linked immunosorbent assay (ELISA) or enzyme-linked immunospot (ELISPOT) technology, with several generations of products available. The diagnostic value of IGRAs in the immunocompromised population is significantly different from that in the immunocompetent population because their results are strongly affected by the host immune function. Both physiological and pathological factors can lead to an immunocompromised situation. We summarized the diagnostic value and clinical recommendations of IGRAs for different immunocompromised populations, including peoplewith physiological factors (pregnant and puerperal women, children, and older people), as well as people with pathological factors (solid organ transplantation recipients, combination with human immunodeficiency virus infection, diabetes mellitus, end-stage renal disease, end-stage liver disease, and chronic immune-mediated inflammatory diseases). Though the performance of IGRAs is not perfect and often requires a combination with other diagnostic strategies, it still has some value in the immunocompromised population. Hopefully, the newly developed IGRAs could better target this population. |
format | Online Article Text |
id | pubmed-8871457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88714572022-02-25 Diagnostic Value of Interferon-Gamma Release Assays for Tuberculosis in the Immunocompromised Population Yang, Ying Wang, Hong-Jiao Hu, Wei-Lin Bai, Guan-Nan Hua, Chun-Zhen Diagnostics (Basel) Review Interferon-gamma release assays (IGRAs) are widely used in the diagnosis of Mycobacterium tuberculosis (M. tuberculosis) infection by detecting interferon-γ released by previously sensitized T-cells in-vitro. Currently, there are two assays based on either enzyme-linked immunosorbent assay (ELISA) or enzyme-linked immunospot (ELISPOT) technology, with several generations of products available. The diagnostic value of IGRAs in the immunocompromised population is significantly different from that in the immunocompetent population because their results are strongly affected by the host immune function. Both physiological and pathological factors can lead to an immunocompromised situation. We summarized the diagnostic value and clinical recommendations of IGRAs for different immunocompromised populations, including peoplewith physiological factors (pregnant and puerperal women, children, and older people), as well as people with pathological factors (solid organ transplantation recipients, combination with human immunodeficiency virus infection, diabetes mellitus, end-stage renal disease, end-stage liver disease, and chronic immune-mediated inflammatory diseases). Though the performance of IGRAs is not perfect and often requires a combination with other diagnostic strategies, it still has some value in the immunocompromised population. Hopefully, the newly developed IGRAs could better target this population. MDPI 2022-02-10 /pmc/articles/PMC8871457/ /pubmed/35204544 http://dx.doi.org/10.3390/diagnostics12020453 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yang, Ying Wang, Hong-Jiao Hu, Wei-Lin Bai, Guan-Nan Hua, Chun-Zhen Diagnostic Value of Interferon-Gamma Release Assays for Tuberculosis in the Immunocompromised Population |
title | Diagnostic Value of Interferon-Gamma Release Assays for Tuberculosis in the Immunocompromised Population |
title_full | Diagnostic Value of Interferon-Gamma Release Assays for Tuberculosis in the Immunocompromised Population |
title_fullStr | Diagnostic Value of Interferon-Gamma Release Assays for Tuberculosis in the Immunocompromised Population |
title_full_unstemmed | Diagnostic Value of Interferon-Gamma Release Assays for Tuberculosis in the Immunocompromised Population |
title_short | Diagnostic Value of Interferon-Gamma Release Assays for Tuberculosis in the Immunocompromised Population |
title_sort | diagnostic value of interferon-gamma release assays for tuberculosis in the immunocompromised population |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871457/ https://www.ncbi.nlm.nih.gov/pubmed/35204544 http://dx.doi.org/10.3390/diagnostics12020453 |
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