Cargando…
The Value of Cytology in the Evaluation of Malignant Pericardial Effusions: A Systematic Review
Pericardial effusions can be caused by diverse etiologies, including heart-related conditions, kidney failure, trauma, infections, autoimmune diseases, and cancer. This systematic review aimed to assess the role of cytology in identifying the most prevalent cancers related to malignant pericardial e...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871495/ https://www.ncbi.nlm.nih.gov/pubmed/35204458 http://dx.doi.org/10.3390/diagnostics12020367 |
_version_ | 1784657009355784192 |
---|---|
author | Shartouni, Ranim Shartouni, Roy Mahmoodi, Maryam Nikas, Ilias P. |
author_facet | Shartouni, Ranim Shartouni, Roy Mahmoodi, Maryam Nikas, Ilias P. |
author_sort | Shartouni, Ranim |
collection | PubMed |
description | Pericardial effusions can be caused by diverse etiologies, including heart-related conditions, kidney failure, trauma, infections, autoimmune diseases, and cancer. This systematic review aimed to assess the role of cytology in identifying the most prevalent cancers related to malignant pericardial effusions (MPEs), the ability of cytology, compared to histology, to detect cancer while evaluating pericardial effusions, and the prognostic impact of MPEs. Four electronic databases were investigated using a predefined algorithm, and specific inclusion and exclusion criteria. We found that the most prevalent primaries associated with MPEs were lung (especially NSCLCs), breast, hematolymphoid, and gastrointestinal cancers. MPEs tended to be hemorrhagic rather than serous or serosanguinous and to occupy larger volumes compared to non-neoplastic effusions. In addition, cytology was shown to exhibit an enhanced ability to detect cancer compared to biopsy in most of the included studies. Lastly, the presence of an MPE was associated with poor prognosis, while survival depended on the specific cancer type detected. Particularly, prognosis was found to be worse when MPEs were caused by lung or gastric cancer, rather than breast or hematolymphoid malignancies. In conclusion, evidence suggests that cytologic evaluation has a significant diagnostic and prognostic impact in patients with MPEs. |
format | Online Article Text |
id | pubmed-8871495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88714952022-02-25 The Value of Cytology in the Evaluation of Malignant Pericardial Effusions: A Systematic Review Shartouni, Ranim Shartouni, Roy Mahmoodi, Maryam Nikas, Ilias P. Diagnostics (Basel) Review Pericardial effusions can be caused by diverse etiologies, including heart-related conditions, kidney failure, trauma, infections, autoimmune diseases, and cancer. This systematic review aimed to assess the role of cytology in identifying the most prevalent cancers related to malignant pericardial effusions (MPEs), the ability of cytology, compared to histology, to detect cancer while evaluating pericardial effusions, and the prognostic impact of MPEs. Four electronic databases were investigated using a predefined algorithm, and specific inclusion and exclusion criteria. We found that the most prevalent primaries associated with MPEs were lung (especially NSCLCs), breast, hematolymphoid, and gastrointestinal cancers. MPEs tended to be hemorrhagic rather than serous or serosanguinous and to occupy larger volumes compared to non-neoplastic effusions. In addition, cytology was shown to exhibit an enhanced ability to detect cancer compared to biopsy in most of the included studies. Lastly, the presence of an MPE was associated with poor prognosis, while survival depended on the specific cancer type detected. Particularly, prognosis was found to be worse when MPEs were caused by lung or gastric cancer, rather than breast or hematolymphoid malignancies. In conclusion, evidence suggests that cytologic evaluation has a significant diagnostic and prognostic impact in patients with MPEs. MDPI 2022-02-01 /pmc/articles/PMC8871495/ /pubmed/35204458 http://dx.doi.org/10.3390/diagnostics12020367 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shartouni, Ranim Shartouni, Roy Mahmoodi, Maryam Nikas, Ilias P. The Value of Cytology in the Evaluation of Malignant Pericardial Effusions: A Systematic Review |
title | The Value of Cytology in the Evaluation of Malignant Pericardial Effusions: A Systematic Review |
title_full | The Value of Cytology in the Evaluation of Malignant Pericardial Effusions: A Systematic Review |
title_fullStr | The Value of Cytology in the Evaluation of Malignant Pericardial Effusions: A Systematic Review |
title_full_unstemmed | The Value of Cytology in the Evaluation of Malignant Pericardial Effusions: A Systematic Review |
title_short | The Value of Cytology in the Evaluation of Malignant Pericardial Effusions: A Systematic Review |
title_sort | value of cytology in the evaluation of malignant pericardial effusions: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871495/ https://www.ncbi.nlm.nih.gov/pubmed/35204458 http://dx.doi.org/10.3390/diagnostics12020367 |
work_keys_str_mv | AT shartouniranim thevalueofcytologyintheevaluationofmalignantpericardialeffusionsasystematicreview AT shartouniroy thevalueofcytologyintheevaluationofmalignantpericardialeffusionsasystematicreview AT mahmoodimaryam thevalueofcytologyintheevaluationofmalignantpericardialeffusionsasystematicreview AT nikasiliasp thevalueofcytologyintheevaluationofmalignantpericardialeffusionsasystematicreview AT shartouniranim valueofcytologyintheevaluationofmalignantpericardialeffusionsasystematicreview AT shartouniroy valueofcytologyintheevaluationofmalignantpericardialeffusionsasystematicreview AT mahmoodimaryam valueofcytologyintheevaluationofmalignantpericardialeffusionsasystematicreview AT nikasiliasp valueofcytologyintheevaluationofmalignantpericardialeffusionsasystematicreview |