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A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report

We describe a 22-year-old woman (2-gravid) case who was referred to our clinic at 18 weeks of gestation for a placenta with vesicular lesions discovered on prenatal examination routine. An ultrasound exam at 31 weeks of gestation showed numerous vesicular lesions, which gradually augmented as the pr...

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Autores principales: Mehedintu, Claudia, Frincu, Francesca, Ionescu, Oana-Maria, Cirstoiu, Monica Mihaela, Sajin, Maria, Olinca, Maria, Bratila, Elvira, Petca, Aida, Carp-Veliscu, Andreea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871501/
https://www.ncbi.nlm.nih.gov/pubmed/35204384
http://dx.doi.org/10.3390/diagnostics12020293
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author Mehedintu, Claudia
Frincu, Francesca
Ionescu, Oana-Maria
Cirstoiu, Monica Mihaela
Sajin, Maria
Olinca, Maria
Bratila, Elvira
Petca, Aida
Carp-Veliscu, Andreea
author_facet Mehedintu, Claudia
Frincu, Francesca
Ionescu, Oana-Maria
Cirstoiu, Monica Mihaela
Sajin, Maria
Olinca, Maria
Bratila, Elvira
Petca, Aida
Carp-Veliscu, Andreea
author_sort Mehedintu, Claudia
collection PubMed
description We describe a 22-year-old woman (2-gravid) case who was referred to our clinic at 18 weeks of gestation for a placenta with vesicular lesions discovered on prenatal examination routine. An ultrasound exam at 31 weeks of gestation showed numerous vesicular lesions, which gradually augmented as the pregnancy advanced. A live normal-appearing fetus was confirmed by intrauterine growth restriction (IUGR). The maternal serum β-human chorionic gonadotropin level remained in normal ranges. At some point, a multidisciplinary medical consensus considered the termination of the pregnancy, but the patient refused to comply. At 33 weeks of gestation, preterm premature rupture of membranes (pPROM) occurred, and she spontaneously delivered a 1600 g healthy female baby with a good long-term outcome. Placental mesenchymal dysplasia (PMD) was retrospectively diagnosed after confronting the data from ultrasound, chorionic villus sampling (CVS), amniocentesis, pathological examination, and immunohistochemical stain. The lack of sufficient reports of PMD determines doctors to be cautious and reserved, approaching these cases more radically than necessary. We reviewed this disease and searched for all cases of PMD associated with healthy, live newborns.
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spelling pubmed-88715012022-02-25 A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report Mehedintu, Claudia Frincu, Francesca Ionescu, Oana-Maria Cirstoiu, Monica Mihaela Sajin, Maria Olinca, Maria Bratila, Elvira Petca, Aida Carp-Veliscu, Andreea Diagnostics (Basel) Review We describe a 22-year-old woman (2-gravid) case who was referred to our clinic at 18 weeks of gestation for a placenta with vesicular lesions discovered on prenatal examination routine. An ultrasound exam at 31 weeks of gestation showed numerous vesicular lesions, which gradually augmented as the pregnancy advanced. A live normal-appearing fetus was confirmed by intrauterine growth restriction (IUGR). The maternal serum β-human chorionic gonadotropin level remained in normal ranges. At some point, a multidisciplinary medical consensus considered the termination of the pregnancy, but the patient refused to comply. At 33 weeks of gestation, preterm premature rupture of membranes (pPROM) occurred, and she spontaneously delivered a 1600 g healthy female baby with a good long-term outcome. Placental mesenchymal dysplasia (PMD) was retrospectively diagnosed after confronting the data from ultrasound, chorionic villus sampling (CVS), amniocentesis, pathological examination, and immunohistochemical stain. The lack of sufficient reports of PMD determines doctors to be cautious and reserved, approaching these cases more radically than necessary. We reviewed this disease and searched for all cases of PMD associated with healthy, live newborns. MDPI 2022-01-24 /pmc/articles/PMC8871501/ /pubmed/35204384 http://dx.doi.org/10.3390/diagnostics12020293 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mehedintu, Claudia
Frincu, Francesca
Ionescu, Oana-Maria
Cirstoiu, Monica Mihaela
Sajin, Maria
Olinca, Maria
Bratila, Elvira
Petca, Aida
Carp-Veliscu, Andreea
A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report
title A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report
title_full A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report
title_fullStr A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report
title_full_unstemmed A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report
title_short A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report
title_sort challenging diagnosis: placental mesenchymal dysplasia—literature review and case report
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871501/
https://www.ncbi.nlm.nih.gov/pubmed/35204384
http://dx.doi.org/10.3390/diagnostics12020293
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