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Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition?
The over-secretion of monoclonal immunoglobulin light chains by clonal B cells followed by the aggregation and extracellular deposition of fibrillar deposits are responsible forthe clinical course AL amyloidosis. It is well documented that silica significantly increases the number of immunoglobulin-...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871531/ https://www.ncbi.nlm.nih.gov/pubmed/35206498 http://dx.doi.org/10.3390/ijerph19042297 |
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author | Gołębiowski, Tomasz Kuźniar, Jakub Porażko, Tomasz Wojtala, Renata Konieczny, Andrzej Krajewska, Magdalena Klinger, Marian |
author_facet | Gołębiowski, Tomasz Kuźniar, Jakub Porażko, Tomasz Wojtala, Renata Konieczny, Andrzej Krajewska, Magdalena Klinger, Marian |
author_sort | Gołębiowski, Tomasz |
collection | PubMed |
description | The over-secretion of monoclonal immunoglobulin light chains by clonal B cells followed by the aggregation and extracellular deposition of fibrillar deposits are responsible forthe clinical course AL amyloidosis. It is well documented that silica significantly increases the number of immunoglobulin-secreting cells. In the present paper, we report on a coal miner with silicosis and fast progressing primary amyloidosis with predominantly heart, kidney, and lung manifestations. Severeheart failure due to myocardial hypertrophy resulted in the patient’s death. We conclude that long-term environmental silica exposure and silica deposition may contribute to the development of monoclonal gammopathy and amyloidosis due to chronic stimulus and the dysregulation of the immune system. |
format | Online Article Text |
id | pubmed-8871531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88715312022-02-25 Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition? Gołębiowski, Tomasz Kuźniar, Jakub Porażko, Tomasz Wojtala, Renata Konieczny, Andrzej Krajewska, Magdalena Klinger, Marian Int J Environ Res Public Health Case Report The over-secretion of monoclonal immunoglobulin light chains by clonal B cells followed by the aggregation and extracellular deposition of fibrillar deposits are responsible forthe clinical course AL amyloidosis. It is well documented that silica significantly increases the number of immunoglobulin-secreting cells. In the present paper, we report on a coal miner with silicosis and fast progressing primary amyloidosis with predominantly heart, kidney, and lung manifestations. Severeheart failure due to myocardial hypertrophy resulted in the patient’s death. We conclude that long-term environmental silica exposure and silica deposition may contribute to the development of monoclonal gammopathy and amyloidosis due to chronic stimulus and the dysregulation of the immune system. MDPI 2022-02-17 /pmc/articles/PMC8871531/ /pubmed/35206498 http://dx.doi.org/10.3390/ijerph19042297 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Gołębiowski, Tomasz Kuźniar, Jakub Porażko, Tomasz Wojtala, Renata Konieczny, Andrzej Krajewska, Magdalena Klinger, Marian Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition? |
title | Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition? |
title_full | Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition? |
title_fullStr | Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition? |
title_full_unstemmed | Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition? |
title_short | Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition? |
title_sort | multisystem amyloidosis in a coal miner with silicosis: is exposure to silica dust a cause of amyloid deposition? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871531/ https://www.ncbi.nlm.nih.gov/pubmed/35206498 http://dx.doi.org/10.3390/ijerph19042297 |
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