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Comparison of Metabolites and Gut Microbes between Patients with Parkinson’s Disease and Healthy Individuals—A Pilot Clinical Observational Study (STROBE Compliant)

Introduction: Even if levodopa, dopamine agonists, and others are used for patients with Parkinson’s disease, the effect is not sustained, and side effects such as motor fluctuation and dyskinesia are more likely to appear as the dose increases. Thus, new approaches for managing Parkinson’s disease...

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Autores principales: Kim, Cheol-Hyun, Jung, Jeeyoun, Lee, Young-ung, Kim, Kwang-ho, Kang, Sunny, Kang, Geon-hui, Chu, Hongmin, Kim, Se-Young, Lee, Sangkwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871597/
https://www.ncbi.nlm.nih.gov/pubmed/35206916
http://dx.doi.org/10.3390/healthcare10020302
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author Kim, Cheol-Hyun
Jung, Jeeyoun
Lee, Young-ung
Kim, Kwang-ho
Kang, Sunny
Kang, Geon-hui
Chu, Hongmin
Kim, Se-Young
Lee, Sangkwan
author_facet Kim, Cheol-Hyun
Jung, Jeeyoun
Lee, Young-ung
Kim, Kwang-ho
Kang, Sunny
Kang, Geon-hui
Chu, Hongmin
Kim, Se-Young
Lee, Sangkwan
author_sort Kim, Cheol-Hyun
collection PubMed
description Introduction: Even if levodopa, dopamine agonists, and others are used for patients with Parkinson’s disease, the effect is not sustained, and side effects such as motor fluctuation and dyskinesia are more likely to appear as the dose increases. Thus, new approaches for managing Parkinson’s disease are needed. This study aimed to compare the metabolites and gut microbes between patients with Parkinson’s disease and healthy individuals. Methods: This was an observational study with a case-control design. Metabolite and gut microbial analyses were performed using blood and stool samples collected from the subjects. Results: Among the metabolites, the acetate, citrate, methionine, and trimethylamine levels were significantly different between the two groups. In the gut microbes, abundance of Bacteroidetes, Prevotella, Phascolarctobacterium, Pseudoflavonifractor, Eisenbergiella, and Gemella were also significantly different between the two groups. Discussion: Metabolites are the products of gut microbes. Therefore, when the gut microbes change, the metabolites change accordingly. Metabolites and gut microbes that were significantly different between the two groups were mostly those involved in lipid and glucose metabolism. Our data may be helpful for the development of new drugs targeting metabolites and gut microbes through large-scale studies in the future.
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spelling pubmed-88715972022-02-25 Comparison of Metabolites and Gut Microbes between Patients with Parkinson’s Disease and Healthy Individuals—A Pilot Clinical Observational Study (STROBE Compliant) Kim, Cheol-Hyun Jung, Jeeyoun Lee, Young-ung Kim, Kwang-ho Kang, Sunny Kang, Geon-hui Chu, Hongmin Kim, Se-Young Lee, Sangkwan Healthcare (Basel) Article Introduction: Even if levodopa, dopamine agonists, and others are used for patients with Parkinson’s disease, the effect is not sustained, and side effects such as motor fluctuation and dyskinesia are more likely to appear as the dose increases. Thus, new approaches for managing Parkinson’s disease are needed. This study aimed to compare the metabolites and gut microbes between patients with Parkinson’s disease and healthy individuals. Methods: This was an observational study with a case-control design. Metabolite and gut microbial analyses were performed using blood and stool samples collected from the subjects. Results: Among the metabolites, the acetate, citrate, methionine, and trimethylamine levels were significantly different between the two groups. In the gut microbes, abundance of Bacteroidetes, Prevotella, Phascolarctobacterium, Pseudoflavonifractor, Eisenbergiella, and Gemella were also significantly different between the two groups. Discussion: Metabolites are the products of gut microbes. Therefore, when the gut microbes change, the metabolites change accordingly. Metabolites and gut microbes that were significantly different between the two groups were mostly those involved in lipid and glucose metabolism. Our data may be helpful for the development of new drugs targeting metabolites and gut microbes through large-scale studies in the future. MDPI 2022-02-04 /pmc/articles/PMC8871597/ /pubmed/35206916 http://dx.doi.org/10.3390/healthcare10020302 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Cheol-Hyun
Jung, Jeeyoun
Lee, Young-ung
Kim, Kwang-ho
Kang, Sunny
Kang, Geon-hui
Chu, Hongmin
Kim, Se-Young
Lee, Sangkwan
Comparison of Metabolites and Gut Microbes between Patients with Parkinson’s Disease and Healthy Individuals—A Pilot Clinical Observational Study (STROBE Compliant)
title Comparison of Metabolites and Gut Microbes between Patients with Parkinson’s Disease and Healthy Individuals—A Pilot Clinical Observational Study (STROBE Compliant)
title_full Comparison of Metabolites and Gut Microbes between Patients with Parkinson’s Disease and Healthy Individuals—A Pilot Clinical Observational Study (STROBE Compliant)
title_fullStr Comparison of Metabolites and Gut Microbes between Patients with Parkinson’s Disease and Healthy Individuals—A Pilot Clinical Observational Study (STROBE Compliant)
title_full_unstemmed Comparison of Metabolites and Gut Microbes between Patients with Parkinson’s Disease and Healthy Individuals—A Pilot Clinical Observational Study (STROBE Compliant)
title_short Comparison of Metabolites and Gut Microbes between Patients with Parkinson’s Disease and Healthy Individuals—A Pilot Clinical Observational Study (STROBE Compliant)
title_sort comparison of metabolites and gut microbes between patients with parkinson’s disease and healthy individuals—a pilot clinical observational study (strobe compliant)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871597/
https://www.ncbi.nlm.nih.gov/pubmed/35206916
http://dx.doi.org/10.3390/healthcare10020302
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