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Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway

CONTEXT: Icariin (ICA) is the main active ingredient of Epimedium brevicornu Maxim (Berberidaceae), which is used in the immune, reproductive, neuroendocrine systems, and anti-aging. OBJECTIVE: To evaluate the effect of ICA on natural aging rat. MATERIALS AND METHODS: 16-month-old Sprague–Dawley (SD...

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Detalles Bibliográficos
Autores principales:	Zheng, Jie, Hu, Shanshan, Wang, Jinxin, Zhang, Xulan, Yuan, Ding, Zhang, Changcheng, Liu, Chaoqi, Wang, Ting, Zhou, Zhiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871627/ https://www.ncbi.nlm.nih.gov/pubmed/33556283 http://dx.doi.org/10.1080/13880209.2021.1878238

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