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Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review
Introduction: Paracetamol is the most commonly used antipyretic and analgesic in pregnancy. It is also increasingly used off-label in the neonatal intensive care unit. Despite the frequent use of paracetamol, concerns have been raised regarding the high variability in neonatal dosing regimens and th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871754/ https://www.ncbi.nlm.nih.gov/pubmed/35206317 http://dx.doi.org/10.3390/ijerph19042128 |
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author | Patel, Ram Sushko, Katelyn van den Anker, John Samiee-Zafarghandy, Samira |
author_facet | Patel, Ram Sushko, Katelyn van den Anker, John Samiee-Zafarghandy, Samira |
author_sort | Patel, Ram |
collection | PubMed |
description | Introduction: Paracetamol is the most commonly used antipyretic and analgesic in pregnancy. It is also increasingly used off-label in the neonatal intensive care unit. Despite the frequent use of paracetamol, concerns have been raised regarding the high variability in neonatal dosing regimens and the long-term safety of early life exposure. Objective: To investigate the available evidence on the long-term safety of prenatal and neonatal paracetamol exposure. Methods: We conducted a systematic search of the electronic databases Ovid Medline, Ovid Embase and Web of Science from inception to August 2021 for original research studies of any design that described the use of paracetamol in the prenatal or neonatal (within the first four weeks of life) periods and examined the occurrence of neurodevelopmental, atopic or reproductive adverse outcomes at or beyond birth. Results: We identified 1313 unique articles and included 30 studies in the final review. Of all studies, 27 (90%), two (7%) and one (3%) were on the long-term safety of prenatal, neonatal and both prenatal and neonatal exposure, respectively. Thirteen (46%), 11 (39%) and four (15%) studies examined neurodevelopmental, atopic and reproductive outcomes. Eleven (100%), 11 (100%), and three (27%) studies on prenatal exposure reported adverse neurodevelopmental, atopic and reproductive outcomes. Only one study found a possible correlation between neonatal paracetamol exposure and long-term adverse outcomes. Conclusions: The available evidence, although limited, suggests a possible association between prenatal paracetamol exposure and an increased risk of neurodevelopmental, atopic and reproductive adverse outcomes. There is an immediate need for robust data on the long-term safety of paracetamol exposure in the prenatal and neonatal periods. |
format | Online Article Text |
id | pubmed-8871754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88717542022-02-25 Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review Patel, Ram Sushko, Katelyn van den Anker, John Samiee-Zafarghandy, Samira Int J Environ Res Public Health Systematic Review Introduction: Paracetamol is the most commonly used antipyretic and analgesic in pregnancy. It is also increasingly used off-label in the neonatal intensive care unit. Despite the frequent use of paracetamol, concerns have been raised regarding the high variability in neonatal dosing regimens and the long-term safety of early life exposure. Objective: To investigate the available evidence on the long-term safety of prenatal and neonatal paracetamol exposure. Methods: We conducted a systematic search of the electronic databases Ovid Medline, Ovid Embase and Web of Science from inception to August 2021 for original research studies of any design that described the use of paracetamol in the prenatal or neonatal (within the first four weeks of life) periods and examined the occurrence of neurodevelopmental, atopic or reproductive adverse outcomes at or beyond birth. Results: We identified 1313 unique articles and included 30 studies in the final review. Of all studies, 27 (90%), two (7%) and one (3%) were on the long-term safety of prenatal, neonatal and both prenatal and neonatal exposure, respectively. Thirteen (46%), 11 (39%) and four (15%) studies examined neurodevelopmental, atopic and reproductive outcomes. Eleven (100%), 11 (100%), and three (27%) studies on prenatal exposure reported adverse neurodevelopmental, atopic and reproductive outcomes. Only one study found a possible correlation between neonatal paracetamol exposure and long-term adverse outcomes. Conclusions: The available evidence, although limited, suggests a possible association between prenatal paracetamol exposure and an increased risk of neurodevelopmental, atopic and reproductive adverse outcomes. There is an immediate need for robust data on the long-term safety of paracetamol exposure in the prenatal and neonatal periods. MDPI 2022-02-14 /pmc/articles/PMC8871754/ /pubmed/35206317 http://dx.doi.org/10.3390/ijerph19042128 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Patel, Ram Sushko, Katelyn van den Anker, John Samiee-Zafarghandy, Samira Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review |
title | Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review |
title_full | Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review |
title_fullStr | Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review |
title_full_unstemmed | Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review |
title_short | Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review |
title_sort | long-term safety of prenatal and neonatal exposure to paracetamol: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871754/ https://www.ncbi.nlm.nih.gov/pubmed/35206317 http://dx.doi.org/10.3390/ijerph19042128 |
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