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Flourishing in Healthcare Trainees: Psychological Well-Being and the Conserved Transcriptional Response to Adversity
While much attention has been paid to healthcare provider and trainee burnout, less is known about provider well-being (i.e., flourishing) or about the effects of well-being on immune function. This study examined the demographic and psycho-social correlates of well-being among healthcare trainees (...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871849/ https://www.ncbi.nlm.nih.gov/pubmed/35206440 http://dx.doi.org/10.3390/ijerph19042255 |
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author | Mascaro, Jennifer S. Wallace, Amanda Hyman, Brooke Haack, Carla Hill, Cherie C. Moore, Miranda A. Lund, Maha B. Nehl, Eric J. Bergquist, Sharon H. Cole, Steve W. |
author_facet | Mascaro, Jennifer S. Wallace, Amanda Hyman, Brooke Haack, Carla Hill, Cherie C. Moore, Miranda A. Lund, Maha B. Nehl, Eric J. Bergquist, Sharon H. Cole, Steve W. |
author_sort | Mascaro, Jennifer S. |
collection | PubMed |
description | While much attention has been paid to healthcare provider and trainee burnout, less is known about provider well-being (i.e., flourishing) or about the effects of well-being on immune function. This study examined the demographic and psycho-social correlates of well-being among healthcare trainees (resident physicians and physician assistant (PA) trainees) and evaluated the association of well-being with the “conserved transcriptional response to adversity” (CTRA) characterized by up-regulated expression of pro-inflammatory genes and down-regulated expression of innate antiviral genes. Participants (n = 58) completed self-reported assessments of sleep disturbance, loneliness, depressive symptoms, anxiety, stress, and well-being (flourishing). Blood sample RNA profiles were analyzed by RNA sequencing to assess the CTRA. Slightly over half (n = 32; 55.2%) of healthcare trainees were categorized as flourishing. Flourishing was less prevalent among primary caregivers, and more prevalent among trainees who exercised more frequently and those with fewest days sick. Loneliness (AOR = 0.75; 95% CI = 0.61, 0.91; p = 0.003) and stress (AOR = 0.65; 95% CI = 0.45, 0.94; p = 0.02) were associated with decreased odds of flourishing when controlling for other variables. Flourishing was associated with down-regulated CTRA gene expression, whereas loneliness was associated with up-regulated CTRA gene expression (both p < 0.05). Assessing these relationships in a larger, multi-site study is of critical importance to inform policy, curricula, and interventions to bolster sustainable trainee well-being. |
format | Online Article Text |
id | pubmed-8871849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88718492022-02-25 Flourishing in Healthcare Trainees: Psychological Well-Being and the Conserved Transcriptional Response to Adversity Mascaro, Jennifer S. Wallace, Amanda Hyman, Brooke Haack, Carla Hill, Cherie C. Moore, Miranda A. Lund, Maha B. Nehl, Eric J. Bergquist, Sharon H. Cole, Steve W. Int J Environ Res Public Health Article While much attention has been paid to healthcare provider and trainee burnout, less is known about provider well-being (i.e., flourishing) or about the effects of well-being on immune function. This study examined the demographic and psycho-social correlates of well-being among healthcare trainees (resident physicians and physician assistant (PA) trainees) and evaluated the association of well-being with the “conserved transcriptional response to adversity” (CTRA) characterized by up-regulated expression of pro-inflammatory genes and down-regulated expression of innate antiviral genes. Participants (n = 58) completed self-reported assessments of sleep disturbance, loneliness, depressive symptoms, anxiety, stress, and well-being (flourishing). Blood sample RNA profiles were analyzed by RNA sequencing to assess the CTRA. Slightly over half (n = 32; 55.2%) of healthcare trainees were categorized as flourishing. Flourishing was less prevalent among primary caregivers, and more prevalent among trainees who exercised more frequently and those with fewest days sick. Loneliness (AOR = 0.75; 95% CI = 0.61, 0.91; p = 0.003) and stress (AOR = 0.65; 95% CI = 0.45, 0.94; p = 0.02) were associated with decreased odds of flourishing when controlling for other variables. Flourishing was associated with down-regulated CTRA gene expression, whereas loneliness was associated with up-regulated CTRA gene expression (both p < 0.05). Assessing these relationships in a larger, multi-site study is of critical importance to inform policy, curricula, and interventions to bolster sustainable trainee well-being. MDPI 2022-02-16 /pmc/articles/PMC8871849/ /pubmed/35206440 http://dx.doi.org/10.3390/ijerph19042255 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mascaro, Jennifer S. Wallace, Amanda Hyman, Brooke Haack, Carla Hill, Cherie C. Moore, Miranda A. Lund, Maha B. Nehl, Eric J. Bergquist, Sharon H. Cole, Steve W. Flourishing in Healthcare Trainees: Psychological Well-Being and the Conserved Transcriptional Response to Adversity |
title | Flourishing in Healthcare Trainees: Psychological Well-Being and the Conserved Transcriptional Response to Adversity |
title_full | Flourishing in Healthcare Trainees: Psychological Well-Being and the Conserved Transcriptional Response to Adversity |
title_fullStr | Flourishing in Healthcare Trainees: Psychological Well-Being and the Conserved Transcriptional Response to Adversity |
title_full_unstemmed | Flourishing in Healthcare Trainees: Psychological Well-Being and the Conserved Transcriptional Response to Adversity |
title_short | Flourishing in Healthcare Trainees: Psychological Well-Being and the Conserved Transcriptional Response to Adversity |
title_sort | flourishing in healthcare trainees: psychological well-being and the conserved transcriptional response to adversity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871849/ https://www.ncbi.nlm.nih.gov/pubmed/35206440 http://dx.doi.org/10.3390/ijerph19042255 |
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