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Nasal Polyposis Quality of Life (NPQ): Development and Validation of the First Specific Quality of Life Questionnaire for Chronic Rhinosinusitis with Nasal Polyps

To date, no disease-specific tool has been available to assess the impact of chronic rhinosinusitis with nasal polyps (CRSwNP) on health-related quality of life (HRQoL). Therefore, the purpose of this study was to develop and validate a questionnaire specifically designed to this aim: the Nasal Poly...

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Autores principales: Baiardini, Ilaria, Paoletti, Giovanni, Mariani, Alessia, Malvezzi, Luca, Pirola, Francesca, Spriano, Giuseppe, Mercante, Giuseppe, Puggioni, Francesca, Racca, Francesca, Melone, Giulio, Malipiero, Giacomo, Ferri, Sebastian, Canonica, Giorgio Walter, Heffler, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871881/
https://www.ncbi.nlm.nih.gov/pubmed/35206869
http://dx.doi.org/10.3390/healthcare10020253
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author Baiardini, Ilaria
Paoletti, Giovanni
Mariani, Alessia
Malvezzi, Luca
Pirola, Francesca
Spriano, Giuseppe
Mercante, Giuseppe
Puggioni, Francesca
Racca, Francesca
Melone, Giulio
Malipiero, Giacomo
Ferri, Sebastian
Canonica, Giorgio Walter
Heffler, Enrico
author_facet Baiardini, Ilaria
Paoletti, Giovanni
Mariani, Alessia
Malvezzi, Luca
Pirola, Francesca
Spriano, Giuseppe
Mercante, Giuseppe
Puggioni, Francesca
Racca, Francesca
Melone, Giulio
Malipiero, Giacomo
Ferri, Sebastian
Canonica, Giorgio Walter
Heffler, Enrico
author_sort Baiardini, Ilaria
collection PubMed
description To date, no disease-specific tool has been available to assess the impact of chronic rhinosinusitis with nasal polyps (CRSwNP) on health-related quality of life (HRQoL). Therefore, the purpose of this study was to develop and validate a questionnaire specifically designed to this aim: the Nasal Polyposis Quality of Life (NPQ) questionnaire. As indicated in the current guidelines, the development and validation of the NPQ occurred in two separate steps involving different groups of patients. The questionnaire was validated by assessing internal structure, consistency, and validity. Responsiveness and sensitivity to changes were also evaluated. In the development process of NPQ an initial list of 40 items was given to 60 patients with CRSwNP; the 27 most significant items were selected and converted into questions. The validation procedure involved 107 patients (mean age 52.9 ± 12.4). NPQ revealed a five-dimensional structure and high levels of internal consistency (Cronbach’s alpha 0.95). Convergent validity (Spearman’ coefficient r = 0.75; p < 0.01), discriminant validity (sensitivity to VAS score), and reliability in a sample of patients with a stable health status (Interclass Coefficient 0.882) were satisfactory. Responsiveness to clinical changes was accomplished. The minimal important difference was 7. NPQ is the first questionnaire for the assessment of HRQoL in CRSwNP. Our results demonstrate that the new tool is valid, reliable, and sensitive to individual changes.
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spelling pubmed-88718812022-02-25 Nasal Polyposis Quality of Life (NPQ): Development and Validation of the First Specific Quality of Life Questionnaire for Chronic Rhinosinusitis with Nasal Polyps Baiardini, Ilaria Paoletti, Giovanni Mariani, Alessia Malvezzi, Luca Pirola, Francesca Spriano, Giuseppe Mercante, Giuseppe Puggioni, Francesca Racca, Francesca Melone, Giulio Malipiero, Giacomo Ferri, Sebastian Canonica, Giorgio Walter Heffler, Enrico Healthcare (Basel) Article To date, no disease-specific tool has been available to assess the impact of chronic rhinosinusitis with nasal polyps (CRSwNP) on health-related quality of life (HRQoL). Therefore, the purpose of this study was to develop and validate a questionnaire specifically designed to this aim: the Nasal Polyposis Quality of Life (NPQ) questionnaire. As indicated in the current guidelines, the development and validation of the NPQ occurred in two separate steps involving different groups of patients. The questionnaire was validated by assessing internal structure, consistency, and validity. Responsiveness and sensitivity to changes were also evaluated. In the development process of NPQ an initial list of 40 items was given to 60 patients with CRSwNP; the 27 most significant items were selected and converted into questions. The validation procedure involved 107 patients (mean age 52.9 ± 12.4). NPQ revealed a five-dimensional structure and high levels of internal consistency (Cronbach’s alpha 0.95). Convergent validity (Spearman’ coefficient r = 0.75; p < 0.01), discriminant validity (sensitivity to VAS score), and reliability in a sample of patients with a stable health status (Interclass Coefficient 0.882) were satisfactory. Responsiveness to clinical changes was accomplished. The minimal important difference was 7. NPQ is the first questionnaire for the assessment of HRQoL in CRSwNP. Our results demonstrate that the new tool is valid, reliable, and sensitive to individual changes. MDPI 2022-01-28 /pmc/articles/PMC8871881/ /pubmed/35206869 http://dx.doi.org/10.3390/healthcare10020253 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baiardini, Ilaria
Paoletti, Giovanni
Mariani, Alessia
Malvezzi, Luca
Pirola, Francesca
Spriano, Giuseppe
Mercante, Giuseppe
Puggioni, Francesca
Racca, Francesca
Melone, Giulio
Malipiero, Giacomo
Ferri, Sebastian
Canonica, Giorgio Walter
Heffler, Enrico
Nasal Polyposis Quality of Life (NPQ): Development and Validation of the First Specific Quality of Life Questionnaire for Chronic Rhinosinusitis with Nasal Polyps
title Nasal Polyposis Quality of Life (NPQ): Development and Validation of the First Specific Quality of Life Questionnaire for Chronic Rhinosinusitis with Nasal Polyps
title_full Nasal Polyposis Quality of Life (NPQ): Development and Validation of the First Specific Quality of Life Questionnaire for Chronic Rhinosinusitis with Nasal Polyps
title_fullStr Nasal Polyposis Quality of Life (NPQ): Development and Validation of the First Specific Quality of Life Questionnaire for Chronic Rhinosinusitis with Nasal Polyps
title_full_unstemmed Nasal Polyposis Quality of Life (NPQ): Development and Validation of the First Specific Quality of Life Questionnaire for Chronic Rhinosinusitis with Nasal Polyps
title_short Nasal Polyposis Quality of Life (NPQ): Development and Validation of the First Specific Quality of Life Questionnaire for Chronic Rhinosinusitis with Nasal Polyps
title_sort nasal polyposis quality of life (npq): development and validation of the first specific quality of life questionnaire for chronic rhinosinusitis with nasal polyps
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871881/
https://www.ncbi.nlm.nih.gov/pubmed/35206869
http://dx.doi.org/10.3390/healthcare10020253
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