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3D Chitosan-Gallic Acid Complexes: Assessment of the Chemical and Biological Properties

Three-dimensional chitosan-gallic acid complexes were proposed and prepared for the first time by a simple adsorption process of gallic acid (GA) on three-dimensional chitosan structures (3D chitosan). Highly porous 3D devices facilitate a high GA load, up to 2015 mmol/kg at pH 4.0. The preservation...

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Autores principales: Marzano, Maria, Borbone, Nicola, Amato, Felice, Oliviero, Giorgia, Fucile, Pierpaolo, Russo, Teresa, Sannino, Filomena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872007/
https://www.ncbi.nlm.nih.gov/pubmed/35200505
http://dx.doi.org/10.3390/gels8020124
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author Marzano, Maria
Borbone, Nicola
Amato, Felice
Oliviero, Giorgia
Fucile, Pierpaolo
Russo, Teresa
Sannino, Filomena
author_facet Marzano, Maria
Borbone, Nicola
Amato, Felice
Oliviero, Giorgia
Fucile, Pierpaolo
Russo, Teresa
Sannino, Filomena
author_sort Marzano, Maria
collection PubMed
description Three-dimensional chitosan-gallic acid complexes were proposed and prepared for the first time by a simple adsorption process of gallic acid (GA) on three-dimensional chitosan structures (3D chitosan). Highly porous 3D devices facilitate a high GA load, up to 2015 mmol/kg at pH 4.0. The preservation of the redox state of GA released from 3D chitosan was confirmed by spectroscopic analyses. The antioxidant activity of 3D chitosan-GA complexes was assessed using the DPPH radical scavenging assay and was found to be dramatically higher than that of free chitosan. The mechanical property of 3D chitosan–GA complexes was also evaluated using a compression test. Finally, 3D chitosan–GA complexes showed a significant antimicrobial capacity against E. coli and S. aureus, selected, respectively, as a model strain for Gram-negative and Gram-positive bacteria. Our study demonstrated a new, simple, and eco-friendly approach to prepare functional chitosan-based complexes for nutraceutical, cosmeceutical, and pharmaceutical applications.
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spelling pubmed-88720072022-02-25 3D Chitosan-Gallic Acid Complexes: Assessment of the Chemical and Biological Properties Marzano, Maria Borbone, Nicola Amato, Felice Oliviero, Giorgia Fucile, Pierpaolo Russo, Teresa Sannino, Filomena Gels Article Three-dimensional chitosan-gallic acid complexes were proposed and prepared for the first time by a simple adsorption process of gallic acid (GA) on three-dimensional chitosan structures (3D chitosan). Highly porous 3D devices facilitate a high GA load, up to 2015 mmol/kg at pH 4.0. The preservation of the redox state of GA released from 3D chitosan was confirmed by spectroscopic analyses. The antioxidant activity of 3D chitosan-GA complexes was assessed using the DPPH radical scavenging assay and was found to be dramatically higher than that of free chitosan. The mechanical property of 3D chitosan–GA complexes was also evaluated using a compression test. Finally, 3D chitosan–GA complexes showed a significant antimicrobial capacity against E. coli and S. aureus, selected, respectively, as a model strain for Gram-negative and Gram-positive bacteria. Our study demonstrated a new, simple, and eco-friendly approach to prepare functional chitosan-based complexes for nutraceutical, cosmeceutical, and pharmaceutical applications. MDPI 2022-02-15 /pmc/articles/PMC8872007/ /pubmed/35200505 http://dx.doi.org/10.3390/gels8020124 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marzano, Maria
Borbone, Nicola
Amato, Felice
Oliviero, Giorgia
Fucile, Pierpaolo
Russo, Teresa
Sannino, Filomena
3D Chitosan-Gallic Acid Complexes: Assessment of the Chemical and Biological Properties
title 3D Chitosan-Gallic Acid Complexes: Assessment of the Chemical and Biological Properties
title_full 3D Chitosan-Gallic Acid Complexes: Assessment of the Chemical and Biological Properties
title_fullStr 3D Chitosan-Gallic Acid Complexes: Assessment of the Chemical and Biological Properties
title_full_unstemmed 3D Chitosan-Gallic Acid Complexes: Assessment of the Chemical and Biological Properties
title_short 3D Chitosan-Gallic Acid Complexes: Assessment of the Chemical and Biological Properties
title_sort 3d chitosan-gallic acid complexes: assessment of the chemical and biological properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872007/
https://www.ncbi.nlm.nih.gov/pubmed/35200505
http://dx.doi.org/10.3390/gels8020124
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