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Functional Innovation through Gene Duplication Followed by Frameshift Mutation
In his influential book “Evolution by Gene Duplication”, Ohno postulated that frameshift mutation could lead to a new function after duplication, but frameshift mutation is generally thought to be deleterious, and thus drew little attention in functional innovation in duplicate evolution. To this en...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872073/ https://www.ncbi.nlm.nih.gov/pubmed/35205235 http://dx.doi.org/10.3390/genes13020190 |
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author | Guo, Baocheng Zou, Ming Sakamoto, Takahiro Innan, Hideki |
author_facet | Guo, Baocheng Zou, Ming Sakamoto, Takahiro Innan, Hideki |
author_sort | Guo, Baocheng |
collection | PubMed |
description | In his influential book “Evolution by Gene Duplication”, Ohno postulated that frameshift mutation could lead to a new function after duplication, but frameshift mutation is generally thought to be deleterious, and thus drew little attention in functional innovation in duplicate evolution. To this end, we here report an exhaustive survey of the genomes of human, mouse, zebrafish, and fruit fly. We identified 80 duplicate genes that involved frameshift mutations after duplication. The frameshift mutation preferentially located close to the C-terminus in most cases (55/88), which indicated that a frameshift mutation that changed the reading frame in a small part at the end of a duplicate may likely have contributed to adaptive evolution (e.g., human genes NOTCH2NL and ARHGAP11B) otherwise too deleterious to survive. A few cases (11/80) involved multiple frameshift mutations, exhibiting various patterns of modifications of the reading frame. Functionality of duplicate genes involving frameshift mutations was confirmed by sequence characteristics and expression profile, suggesting a potential role of frameshift mutation in creating functional novelty. We thus showed that genomes have non-negligible numbers of genes that have experienced frameshift mutations following gene duplication. Our results demonstrated the potential importance of frameshift mutations in molecular evolution, as Ohno verbally argued 50 years ago. |
format | Online Article Text |
id | pubmed-8872073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88720732022-02-25 Functional Innovation through Gene Duplication Followed by Frameshift Mutation Guo, Baocheng Zou, Ming Sakamoto, Takahiro Innan, Hideki Genes (Basel) Brief Report In his influential book “Evolution by Gene Duplication”, Ohno postulated that frameshift mutation could lead to a new function after duplication, but frameshift mutation is generally thought to be deleterious, and thus drew little attention in functional innovation in duplicate evolution. To this end, we here report an exhaustive survey of the genomes of human, mouse, zebrafish, and fruit fly. We identified 80 duplicate genes that involved frameshift mutations after duplication. The frameshift mutation preferentially located close to the C-terminus in most cases (55/88), which indicated that a frameshift mutation that changed the reading frame in a small part at the end of a duplicate may likely have contributed to adaptive evolution (e.g., human genes NOTCH2NL and ARHGAP11B) otherwise too deleterious to survive. A few cases (11/80) involved multiple frameshift mutations, exhibiting various patterns of modifications of the reading frame. Functionality of duplicate genes involving frameshift mutations was confirmed by sequence characteristics and expression profile, suggesting a potential role of frameshift mutation in creating functional novelty. We thus showed that genomes have non-negligible numbers of genes that have experienced frameshift mutations following gene duplication. Our results demonstrated the potential importance of frameshift mutations in molecular evolution, as Ohno verbally argued 50 years ago. MDPI 2022-01-21 /pmc/articles/PMC8872073/ /pubmed/35205235 http://dx.doi.org/10.3390/genes13020190 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Guo, Baocheng Zou, Ming Sakamoto, Takahiro Innan, Hideki Functional Innovation through Gene Duplication Followed by Frameshift Mutation |
title | Functional Innovation through Gene Duplication Followed by Frameshift Mutation |
title_full | Functional Innovation through Gene Duplication Followed by Frameshift Mutation |
title_fullStr | Functional Innovation through Gene Duplication Followed by Frameshift Mutation |
title_full_unstemmed | Functional Innovation through Gene Duplication Followed by Frameshift Mutation |
title_short | Functional Innovation through Gene Duplication Followed by Frameshift Mutation |
title_sort | functional innovation through gene duplication followed by frameshift mutation |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872073/ https://www.ncbi.nlm.nih.gov/pubmed/35205235 http://dx.doi.org/10.3390/genes13020190 |
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