Cargando…

Increase in Ribosomal Fidelity Benefits Salmonella upon Bile Salt Exposure

Translational fidelity is maintained by multiple quality control steps in all three domains of life. Increased translational errors (mistranslation) occur due to genetic mutations and external stresses. Severe mistranslation is generally harmful, but moderate levels of mistranslation may be favored...

Descripción completa

Detalles Bibliográficos
Autores principales: Lyu, Zhihui, Ling, Jiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872077/
https://www.ncbi.nlm.nih.gov/pubmed/35205229
http://dx.doi.org/10.3390/genes13020184
_version_ 1784657148254355456
author Lyu, Zhihui
Ling, Jiqiang
author_facet Lyu, Zhihui
Ling, Jiqiang
author_sort Lyu, Zhihui
collection PubMed
description Translational fidelity is maintained by multiple quality control steps in all three domains of life. Increased translational errors (mistranslation) occur due to genetic mutations and external stresses. Severe mistranslation is generally harmful, but moderate levels of mistranslation may be favored under certain conditions. To date, little is known about the link between translational fidelity and host–pathogen interactions. Salmonella enterica can survive in the gall bladder during systemic or chronic infections due to bile resistance. Here we show that increased translational fidelity contributes to the fitness of Salmonella upon bile salt exposure, and the improved fitness depends on an increased level of intracellular adenosine triphosphate (ATP). Our work thus reveals a previously unknown linkage between translational fidelity and bacterial fitness under bile stress.
format Online
Article
Text
id pubmed-8872077
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88720772022-02-25 Increase in Ribosomal Fidelity Benefits Salmonella upon Bile Salt Exposure Lyu, Zhihui Ling, Jiqiang Genes (Basel) Article Translational fidelity is maintained by multiple quality control steps in all three domains of life. Increased translational errors (mistranslation) occur due to genetic mutations and external stresses. Severe mistranslation is generally harmful, but moderate levels of mistranslation may be favored under certain conditions. To date, little is known about the link between translational fidelity and host–pathogen interactions. Salmonella enterica can survive in the gall bladder during systemic or chronic infections due to bile resistance. Here we show that increased translational fidelity contributes to the fitness of Salmonella upon bile salt exposure, and the improved fitness depends on an increased level of intracellular adenosine triphosphate (ATP). Our work thus reveals a previously unknown linkage between translational fidelity and bacterial fitness under bile stress. MDPI 2022-01-21 /pmc/articles/PMC8872077/ /pubmed/35205229 http://dx.doi.org/10.3390/genes13020184 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lyu, Zhihui
Ling, Jiqiang
Increase in Ribosomal Fidelity Benefits Salmonella upon Bile Salt Exposure
title Increase in Ribosomal Fidelity Benefits Salmonella upon Bile Salt Exposure
title_full Increase in Ribosomal Fidelity Benefits Salmonella upon Bile Salt Exposure
title_fullStr Increase in Ribosomal Fidelity Benefits Salmonella upon Bile Salt Exposure
title_full_unstemmed Increase in Ribosomal Fidelity Benefits Salmonella upon Bile Salt Exposure
title_short Increase in Ribosomal Fidelity Benefits Salmonella upon Bile Salt Exposure
title_sort increase in ribosomal fidelity benefits salmonella upon bile salt exposure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872077/
https://www.ncbi.nlm.nih.gov/pubmed/35205229
http://dx.doi.org/10.3390/genes13020184
work_keys_str_mv AT lyuzhihui increaseinribosomalfidelitybenefitssalmonellauponbilesaltexposure
AT lingjiqiang increaseinribosomalfidelitybenefitssalmonellauponbilesaltexposure