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Herb-Induced Liver Injury—A Challenging Diagnosis

Herb-induced liver injury (HILI) can be caused by supplements containing herbs, natural products, and products used in traditional medicine. Herbal products’ most common adverse reaction is hepatotoxicity. Almost every plant part can be used to make herbal products, and these products can come in ma...

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Detalles Bibliográficos
Autores principales: Nunes, David Ricardo da Conceição Marçal Alves, Monteiro, Cristina Sofia de Jesus, dos Santos, Jorge Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872293/
https://www.ncbi.nlm.nih.gov/pubmed/35206892
http://dx.doi.org/10.3390/healthcare10020278
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author Nunes, David Ricardo da Conceição Marçal Alves
Monteiro, Cristina Sofia de Jesus
dos Santos, Jorge Luiz
author_facet Nunes, David Ricardo da Conceição Marçal Alves
Monteiro, Cristina Sofia de Jesus
dos Santos, Jorge Luiz
author_sort Nunes, David Ricardo da Conceição Marçal Alves
collection PubMed
description Herb-induced liver injury (HILI) can be caused by supplements containing herbs, natural products, and products used in traditional medicine. Herbal products’ most common adverse reaction is hepatotoxicity. Almost every plant part can be used to make herbal products, and these products can come in many different forms, such as teas, powders, oils, creams, capsules, and injectables. HILI incidence and prevalence are hard to estimate and vary from study to study because of insufficient large-scale prospective studies. The diagnosis of HILI is a challenging process that requires not only insight but also a high degree of suspicion by the clinician. HILI presents with unspecific symptoms and is a diagnosis of exclusion. For diagnosis, it is necessary to make a causality assessment; the Council for International Organizations of Medical Sciences assessment is the preferred method worldwide. The most effective treatment is the suspension of the use of the suspected herbal product and close monitoring of liver function. The objective of this review is to highlight the necessary steps for the clinician to follow to reach a correct diagnosis of herb-induced liver injury. Further studies of HILI are needed to better understand its complexity and prevent increased morbidity and mortality.
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spelling pubmed-88722932022-02-25 Herb-Induced Liver Injury—A Challenging Diagnosis Nunes, David Ricardo da Conceição Marçal Alves Monteiro, Cristina Sofia de Jesus dos Santos, Jorge Luiz Healthcare (Basel) Review Herb-induced liver injury (HILI) can be caused by supplements containing herbs, natural products, and products used in traditional medicine. Herbal products’ most common adverse reaction is hepatotoxicity. Almost every plant part can be used to make herbal products, and these products can come in many different forms, such as teas, powders, oils, creams, capsules, and injectables. HILI incidence and prevalence are hard to estimate and vary from study to study because of insufficient large-scale prospective studies. The diagnosis of HILI is a challenging process that requires not only insight but also a high degree of suspicion by the clinician. HILI presents with unspecific symptoms and is a diagnosis of exclusion. For diagnosis, it is necessary to make a causality assessment; the Council for International Organizations of Medical Sciences assessment is the preferred method worldwide. The most effective treatment is the suspension of the use of the suspected herbal product and close monitoring of liver function. The objective of this review is to highlight the necessary steps for the clinician to follow to reach a correct diagnosis of herb-induced liver injury. Further studies of HILI are needed to better understand its complexity and prevent increased morbidity and mortality. MDPI 2022-01-31 /pmc/articles/PMC8872293/ /pubmed/35206892 http://dx.doi.org/10.3390/healthcare10020278 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nunes, David Ricardo da Conceição Marçal Alves
Monteiro, Cristina Sofia de Jesus
dos Santos, Jorge Luiz
Herb-Induced Liver Injury—A Challenging Diagnosis
title Herb-Induced Liver Injury—A Challenging Diagnosis
title_full Herb-Induced Liver Injury—A Challenging Diagnosis
title_fullStr Herb-Induced Liver Injury—A Challenging Diagnosis
title_full_unstemmed Herb-Induced Liver Injury—A Challenging Diagnosis
title_short Herb-Induced Liver Injury—A Challenging Diagnosis
title_sort herb-induced liver injury—a challenging diagnosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872293/
https://www.ncbi.nlm.nih.gov/pubmed/35206892
http://dx.doi.org/10.3390/healthcare10020278
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