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Herb-Induced Liver Injury—A Challenging Diagnosis
Herb-induced liver injury (HILI) can be caused by supplements containing herbs, natural products, and products used in traditional medicine. Herbal products’ most common adverse reaction is hepatotoxicity. Almost every plant part can be used to make herbal products, and these products can come in ma...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872293/ https://www.ncbi.nlm.nih.gov/pubmed/35206892 http://dx.doi.org/10.3390/healthcare10020278 |
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author | Nunes, David Ricardo da Conceição Marçal Alves Monteiro, Cristina Sofia de Jesus dos Santos, Jorge Luiz |
author_facet | Nunes, David Ricardo da Conceição Marçal Alves Monteiro, Cristina Sofia de Jesus dos Santos, Jorge Luiz |
author_sort | Nunes, David Ricardo da Conceição Marçal Alves |
collection | PubMed |
description | Herb-induced liver injury (HILI) can be caused by supplements containing herbs, natural products, and products used in traditional medicine. Herbal products’ most common adverse reaction is hepatotoxicity. Almost every plant part can be used to make herbal products, and these products can come in many different forms, such as teas, powders, oils, creams, capsules, and injectables. HILI incidence and prevalence are hard to estimate and vary from study to study because of insufficient large-scale prospective studies. The diagnosis of HILI is a challenging process that requires not only insight but also a high degree of suspicion by the clinician. HILI presents with unspecific symptoms and is a diagnosis of exclusion. For diagnosis, it is necessary to make a causality assessment; the Council for International Organizations of Medical Sciences assessment is the preferred method worldwide. The most effective treatment is the suspension of the use of the suspected herbal product and close monitoring of liver function. The objective of this review is to highlight the necessary steps for the clinician to follow to reach a correct diagnosis of herb-induced liver injury. Further studies of HILI are needed to better understand its complexity and prevent increased morbidity and mortality. |
format | Online Article Text |
id | pubmed-8872293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88722932022-02-25 Herb-Induced Liver Injury—A Challenging Diagnosis Nunes, David Ricardo da Conceição Marçal Alves Monteiro, Cristina Sofia de Jesus dos Santos, Jorge Luiz Healthcare (Basel) Review Herb-induced liver injury (HILI) can be caused by supplements containing herbs, natural products, and products used in traditional medicine. Herbal products’ most common adverse reaction is hepatotoxicity. Almost every plant part can be used to make herbal products, and these products can come in many different forms, such as teas, powders, oils, creams, capsules, and injectables. HILI incidence and prevalence are hard to estimate and vary from study to study because of insufficient large-scale prospective studies. The diagnosis of HILI is a challenging process that requires not only insight but also a high degree of suspicion by the clinician. HILI presents with unspecific symptoms and is a diagnosis of exclusion. For diagnosis, it is necessary to make a causality assessment; the Council for International Organizations of Medical Sciences assessment is the preferred method worldwide. The most effective treatment is the suspension of the use of the suspected herbal product and close monitoring of liver function. The objective of this review is to highlight the necessary steps for the clinician to follow to reach a correct diagnosis of herb-induced liver injury. Further studies of HILI are needed to better understand its complexity and prevent increased morbidity and mortality. MDPI 2022-01-31 /pmc/articles/PMC8872293/ /pubmed/35206892 http://dx.doi.org/10.3390/healthcare10020278 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nunes, David Ricardo da Conceição Marçal Alves Monteiro, Cristina Sofia de Jesus dos Santos, Jorge Luiz Herb-Induced Liver Injury—A Challenging Diagnosis |
title | Herb-Induced Liver Injury—A Challenging Diagnosis |
title_full | Herb-Induced Liver Injury—A Challenging Diagnosis |
title_fullStr | Herb-Induced Liver Injury—A Challenging Diagnosis |
title_full_unstemmed | Herb-Induced Liver Injury—A Challenging Diagnosis |
title_short | Herb-Induced Liver Injury—A Challenging Diagnosis |
title_sort | herb-induced liver injury—a challenging diagnosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872293/ https://www.ncbi.nlm.nih.gov/pubmed/35206892 http://dx.doi.org/10.3390/healthcare10020278 |
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