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MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma
MicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length, functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators that regulate gene expression by suppressing gene translation through gene silencing/degradation, or by promoting translat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872331/ https://www.ncbi.nlm.nih.gov/pubmed/35205289 http://dx.doi.org/10.3390/genes13020244 |
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author | Setlai, Botle Precious Hull, Rodney Reis, Rui Manuel Agbor, Cyril Ambele, Melvin Anyasi Mulaudzi, Thanyani Victor Dlamini, Zodwa |
author_facet | Setlai, Botle Precious Hull, Rodney Reis, Rui Manuel Agbor, Cyril Ambele, Melvin Anyasi Mulaudzi, Thanyani Victor Dlamini, Zodwa |
author_sort | Setlai, Botle Precious |
collection | PubMed |
description | MicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length, functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators that regulate gene expression by suppressing gene translation through gene silencing/degradation, or by promoting translation of messenger RNA (mRNA) into proteins. Circulating miRNAs have attracted attention as possible prognostic markers of cancer, which could aid in the early detection of the disease. Epithelial to mesenchymal transition (EMT) has been implicated in tumorigenic processes, primarily by promoting tumor invasiveness and metastatic activity; this is a process that could be manipulated to halt or prevent brain metastasis. Studies show that miRNAs influence the function of EMT in glioblastomas. Thus, miRNA-related EMT can be exploited as a potential therapeutic target in glioblastomas. This review points out the interrelation between miRNA and EMT signatures, and how they can be used as reliable molecular signatures for diagnostic purposes or targeted therapy in glioblastomas. |
format | Online Article Text |
id | pubmed-8872331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88723312022-02-25 MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma Setlai, Botle Precious Hull, Rodney Reis, Rui Manuel Agbor, Cyril Ambele, Melvin Anyasi Mulaudzi, Thanyani Victor Dlamini, Zodwa Genes (Basel) Review MicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length, functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators that regulate gene expression by suppressing gene translation through gene silencing/degradation, or by promoting translation of messenger RNA (mRNA) into proteins. Circulating miRNAs have attracted attention as possible prognostic markers of cancer, which could aid in the early detection of the disease. Epithelial to mesenchymal transition (EMT) has been implicated in tumorigenic processes, primarily by promoting tumor invasiveness and metastatic activity; this is a process that could be manipulated to halt or prevent brain metastasis. Studies show that miRNAs influence the function of EMT in glioblastomas. Thus, miRNA-related EMT can be exploited as a potential therapeutic target in glioblastomas. This review points out the interrelation between miRNA and EMT signatures, and how they can be used as reliable molecular signatures for diagnostic purposes or targeted therapy in glioblastomas. MDPI 2022-01-27 /pmc/articles/PMC8872331/ /pubmed/35205289 http://dx.doi.org/10.3390/genes13020244 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Setlai, Botle Precious Hull, Rodney Reis, Rui Manuel Agbor, Cyril Ambele, Melvin Anyasi Mulaudzi, Thanyani Victor Dlamini, Zodwa MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
title | MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
title_full | MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
title_fullStr | MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
title_full_unstemmed | MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
title_short | MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
title_sort | microrna interrelated epithelial mesenchymal transition (emt) in glioblastoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872331/ https://www.ncbi.nlm.nih.gov/pubmed/35205289 http://dx.doi.org/10.3390/genes13020244 |
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