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Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference

Environmental exposures to a myriad of chemicals are associated with adverse health effects in humans, while good nutrition is associated with improved health. Single chemical in vivo and in vitro studies demonstrate causal links between the chemicals and outcomes, but such studies do not represent...

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Autores principales: Gennings, Chris, Svensson, Katherine, Wolk, Alicja, Lindh, Christian, Kiviranta, Hannu, Bornehag, Carl-Gustaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872366/
https://www.ncbi.nlm.nih.gov/pubmed/35206461
http://dx.doi.org/10.3390/ijerph19042273
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author Gennings, Chris
Svensson, Katherine
Wolk, Alicja
Lindh, Christian
Kiviranta, Hannu
Bornehag, Carl-Gustaf
author_facet Gennings, Chris
Svensson, Katherine
Wolk, Alicja
Lindh, Christian
Kiviranta, Hannu
Bornehag, Carl-Gustaf
author_sort Gennings, Chris
collection PubMed
description Environmental exposures to a myriad of chemicals are associated with adverse health effects in humans, while good nutrition is associated with improved health. Single chemical in vivo and in vitro studies demonstrate causal links between the chemicals and outcomes, but such studies do not represent human exposure to environmental mixtures. One way of summarizing the effect of the joint action of chemical mixtures is through an empirically weighted index using weighted quantile sum (WQS) regression. My Nutrition Index (MNI) is a metric of overall dietary nutrition based on guideline values, including for pregnant women. Our objective is to demonstrate the use of an index as a metric for more causally linking human exposure to health outcomes using observational data. We use both a WQS index of 26 endocrine-disrupting chemicals (EDCs) and MNI using data from the SELMA pregnancy cohort to conduct causal inference using g-computation with counterfactuals for assumed either reduced prenatal EDC exposures or improved prenatal nutrition. Reducing the EDC exposure using the WQS index as a metric or improving dietary nutrition using MNI as a metric, the counterfactuals in a causal inference with one SD change indicate significant improvement in cognitive function. Evaluation of such a strategy may support decision makers for risk management of EDCs and individual choices for improving dietary nutrition.
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spelling pubmed-88723662022-02-25 Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference Gennings, Chris Svensson, Katherine Wolk, Alicja Lindh, Christian Kiviranta, Hannu Bornehag, Carl-Gustaf Int J Environ Res Public Health Article Environmental exposures to a myriad of chemicals are associated with adverse health effects in humans, while good nutrition is associated with improved health. Single chemical in vivo and in vitro studies demonstrate causal links between the chemicals and outcomes, but such studies do not represent human exposure to environmental mixtures. One way of summarizing the effect of the joint action of chemical mixtures is through an empirically weighted index using weighted quantile sum (WQS) regression. My Nutrition Index (MNI) is a metric of overall dietary nutrition based on guideline values, including for pregnant women. Our objective is to demonstrate the use of an index as a metric for more causally linking human exposure to health outcomes using observational data. We use both a WQS index of 26 endocrine-disrupting chemicals (EDCs) and MNI using data from the SELMA pregnancy cohort to conduct causal inference using g-computation with counterfactuals for assumed either reduced prenatal EDC exposures or improved prenatal nutrition. Reducing the EDC exposure using the WQS index as a metric or improving dietary nutrition using MNI as a metric, the counterfactuals in a causal inference with one SD change indicate significant improvement in cognitive function. Evaluation of such a strategy may support decision makers for risk management of EDCs and individual choices for improving dietary nutrition. MDPI 2022-02-17 /pmc/articles/PMC8872366/ /pubmed/35206461 http://dx.doi.org/10.3390/ijerph19042273 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gennings, Chris
Svensson, Katherine
Wolk, Alicja
Lindh, Christian
Kiviranta, Hannu
Bornehag, Carl-Gustaf
Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference
title Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference
title_full Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference
title_fullStr Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference
title_full_unstemmed Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference
title_short Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference
title_sort using metrics of a mixture effect and nutrition from an observational study for consideration towards causal inference
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872366/
https://www.ncbi.nlm.nih.gov/pubmed/35206461
http://dx.doi.org/10.3390/ijerph19042273
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