A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers

miRNAs are small endogenous conserved non-coding RNA molecules that regulate post-transcriptional gene expression through mRNA degradation or translational inhibition, modulating nearly 60% of human genes. Cystic diseases are characterized by the presence of abnormal fluid-filled sacs in the body, a...

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Autores principales: Ruiz-Manriquez, Luis M., Ledesma Pacheco, Schoenstatt Janin, Medina-Gomez, Daniel, Uriostegui-Pena, Andrea G., Estrada-Meza, Carolina, Bandyopadhyay, Anindya, Pathak, Surajit, Banerjee, Antara, Chakraborty, Samik, Srivastava, Aashish, Paul, Sujay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872411/
https://www.ncbi.nlm.nih.gov/pubmed/35205236
http://dx.doi.org/10.3390/genes13020191
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author Ruiz-Manriquez, Luis M.
Ledesma Pacheco, Schoenstatt Janin
Medina-Gomez, Daniel
Uriostegui-Pena, Andrea G.
Estrada-Meza, Carolina
Bandyopadhyay, Anindya
Pathak, Surajit
Banerjee, Antara
Chakraborty, Samik
Srivastava, Aashish
Paul, Sujay
author_facet Ruiz-Manriquez, Luis M.
Ledesma Pacheco, Schoenstatt Janin
Medina-Gomez, Daniel
Uriostegui-Pena, Andrea G.
Estrada-Meza, Carolina
Bandyopadhyay, Anindya
Pathak, Surajit
Banerjee, Antara
Chakraborty, Samik
Srivastava, Aashish
Paul, Sujay
author_sort Ruiz-Manriquez, Luis M.
collection PubMed
description miRNAs are small endogenous conserved non-coding RNA molecules that regulate post-transcriptional gene expression through mRNA degradation or translational inhibition, modulating nearly 60% of human genes. Cystic diseases are characterized by the presence of abnormal fluid-filled sacs in the body, and though most cysts are benign, they can grow inside tumors and turn malignant. Recent evidence has revealed that the aberrant expression of a number of miRNAs present in extracellular fluids, including plasma or serum, urine, saliva, follicular fluid, and semen, contribute to different cystic pathologies. This review aims to describe the role of different miRNAs in three worldwide relevant cystic diseases: polycystic ovarian syndrome (PCOS), polycystic kidney disease (PKD), and pancreatic cyst tumors (PCTs), as well as their potential use as novel biomarkers.
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spelling pubmed-88724112022-02-25 A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers Ruiz-Manriquez, Luis M. Ledesma Pacheco, Schoenstatt Janin Medina-Gomez, Daniel Uriostegui-Pena, Andrea G. Estrada-Meza, Carolina Bandyopadhyay, Anindya Pathak, Surajit Banerjee, Antara Chakraborty, Samik Srivastava, Aashish Paul, Sujay Genes (Basel) Review miRNAs are small endogenous conserved non-coding RNA molecules that regulate post-transcriptional gene expression through mRNA degradation or translational inhibition, modulating nearly 60% of human genes. Cystic diseases are characterized by the presence of abnormal fluid-filled sacs in the body, and though most cysts are benign, they can grow inside tumors and turn malignant. Recent evidence has revealed that the aberrant expression of a number of miRNAs present in extracellular fluids, including plasma or serum, urine, saliva, follicular fluid, and semen, contribute to different cystic pathologies. This review aims to describe the role of different miRNAs in three worldwide relevant cystic diseases: polycystic ovarian syndrome (PCOS), polycystic kidney disease (PKD), and pancreatic cyst tumors (PCTs), as well as their potential use as novel biomarkers. MDPI 2022-01-22 /pmc/articles/PMC8872411/ /pubmed/35205236 http://dx.doi.org/10.3390/genes13020191 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ruiz-Manriquez, Luis M.
Ledesma Pacheco, Schoenstatt Janin
Medina-Gomez, Daniel
Uriostegui-Pena, Andrea G.
Estrada-Meza, Carolina
Bandyopadhyay, Anindya
Pathak, Surajit
Banerjee, Antara
Chakraborty, Samik
Srivastava, Aashish
Paul, Sujay
A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers
title A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers
title_full A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers
title_fullStr A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers
title_full_unstemmed A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers
title_short A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers
title_sort brief review on the regulatory roles of micrornas in cystic diseases and their use as potential biomarkers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872411/
https://www.ncbi.nlm.nih.gov/pubmed/35205236
http://dx.doi.org/10.3390/genes13020191
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