Cargando…
Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature
Background: Intranasal dexmedetomidine (IN DEX) is a relatively new sedative agent with supporting evidence on its efficacy and safety, which can be used for procedural sedation in children, and could have a major role in auditory brainstem response testing, especially in the case of non-cooperative...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872591/ https://www.ncbi.nlm.nih.gov/pubmed/35206901 http://dx.doi.org/10.3390/healthcare10020287 |
_version_ | 1784657275283046400 |
---|---|
author | Marra, Pasquale Di Stadio, Arianna Colacurcio, Vito Scarpa, Alfonso La Mantia, Ignazio Salzano, Francesco Antonio De Luca, Pietro |
author_facet | Marra, Pasquale Di Stadio, Arianna Colacurcio, Vito Scarpa, Alfonso La Mantia, Ignazio Salzano, Francesco Antonio De Luca, Pietro |
author_sort | Marra, Pasquale |
collection | PubMed |
description | Background: Intranasal dexmedetomidine (IN DEX) is a relatively new sedative agent with supporting evidence on its efficacy and safety, which can be used for procedural sedation in children, and could have a major role in auditory brainstem response testing, especially in the case of non-cooperative children. The goal of this systematic review is to assess the role of IN DEX in ABR testing, evaluating the reported protocol, potential, and limits. Methods: We performed a comprehensive search strategy on PubMed, Scopus, and Google Scholar, including studies in English on the pediatric population, without time restrictions. Results: Six articles, published between 2016 and 2021, were included in the systematic review. Sedation effectiveness was high across the studies, except for one study; 3 μg/kg was the dosing most often used. A comparison group was present in three studies, with oral chloral hydrate as the drug of comparison. Adverse effects were rarely reported. Conclusion: This systematic review showed how IN DEX can represent an adequate sedative for children undergoing ABR testing; larger and more rigorous trials are warranted in order to recommend its systematic utilization. |
format | Online Article Text |
id | pubmed-8872591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88725912022-02-25 Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature Marra, Pasquale Di Stadio, Arianna Colacurcio, Vito Scarpa, Alfonso La Mantia, Ignazio Salzano, Francesco Antonio De Luca, Pietro Healthcare (Basel) Systematic Review Background: Intranasal dexmedetomidine (IN DEX) is a relatively new sedative agent with supporting evidence on its efficacy and safety, which can be used for procedural sedation in children, and could have a major role in auditory brainstem response testing, especially in the case of non-cooperative children. The goal of this systematic review is to assess the role of IN DEX in ABR testing, evaluating the reported protocol, potential, and limits. Methods: We performed a comprehensive search strategy on PubMed, Scopus, and Google Scholar, including studies in English on the pediatric population, without time restrictions. Results: Six articles, published between 2016 and 2021, were included in the systematic review. Sedation effectiveness was high across the studies, except for one study; 3 μg/kg was the dosing most often used. A comparison group was present in three studies, with oral chloral hydrate as the drug of comparison. Adverse effects were rarely reported. Conclusion: This systematic review showed how IN DEX can represent an adequate sedative for children undergoing ABR testing; larger and more rigorous trials are warranted in order to recommend its systematic utilization. MDPI 2022-02-01 /pmc/articles/PMC8872591/ /pubmed/35206901 http://dx.doi.org/10.3390/healthcare10020287 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Marra, Pasquale Di Stadio, Arianna Colacurcio, Vito Scarpa, Alfonso La Mantia, Ignazio Salzano, Francesco Antonio De Luca, Pietro Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature |
title | Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature |
title_full | Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature |
title_fullStr | Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature |
title_full_unstemmed | Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature |
title_short | Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature |
title_sort | sedation with intranasal dexmedetomidine in the pediatric population for auditory brainstem response testing: review of the existing literature |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872591/ https://www.ncbi.nlm.nih.gov/pubmed/35206901 http://dx.doi.org/10.3390/healthcare10020287 |
work_keys_str_mv | AT marrapasquale sedationwithintranasaldexmedetomidineinthepediatricpopulationforauditorybrainstemresponsetestingreviewoftheexistingliterature AT distadioarianna sedationwithintranasaldexmedetomidineinthepediatricpopulationforauditorybrainstemresponsetestingreviewoftheexistingliterature AT colacurciovito sedationwithintranasaldexmedetomidineinthepediatricpopulationforauditorybrainstemresponsetestingreviewoftheexistingliterature AT scarpaalfonso sedationwithintranasaldexmedetomidineinthepediatricpopulationforauditorybrainstemresponsetestingreviewoftheexistingliterature AT lamantiaignazio sedationwithintranasaldexmedetomidineinthepediatricpopulationforauditorybrainstemresponsetestingreviewoftheexistingliterature AT salzanofrancescoantonio sedationwithintranasaldexmedetomidineinthepediatricpopulationforauditorybrainstemresponsetestingreviewoftheexistingliterature AT delucapietro sedationwithintranasaldexmedetomidineinthepediatricpopulationforauditorybrainstemresponsetestingreviewoftheexistingliterature |