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Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature

Background: Intranasal dexmedetomidine (IN DEX) is a relatively new sedative agent with supporting evidence on its efficacy and safety, which can be used for procedural sedation in children, and could have a major role in auditory brainstem response testing, especially in the case of non-cooperative...

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Autores principales: Marra, Pasquale, Di Stadio, Arianna, Colacurcio, Vito, Scarpa, Alfonso, La Mantia, Ignazio, Salzano, Francesco Antonio, De Luca, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872591/
https://www.ncbi.nlm.nih.gov/pubmed/35206901
http://dx.doi.org/10.3390/healthcare10020287
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author Marra, Pasquale
Di Stadio, Arianna
Colacurcio, Vito
Scarpa, Alfonso
La Mantia, Ignazio
Salzano, Francesco Antonio
De Luca, Pietro
author_facet Marra, Pasquale
Di Stadio, Arianna
Colacurcio, Vito
Scarpa, Alfonso
La Mantia, Ignazio
Salzano, Francesco Antonio
De Luca, Pietro
author_sort Marra, Pasquale
collection PubMed
description Background: Intranasal dexmedetomidine (IN DEX) is a relatively new sedative agent with supporting evidence on its efficacy and safety, which can be used for procedural sedation in children, and could have a major role in auditory brainstem response testing, especially in the case of non-cooperative children. The goal of this systematic review is to assess the role of IN DEX in ABR testing, evaluating the reported protocol, potential, and limits. Methods: We performed a comprehensive search strategy on PubMed, Scopus, and Google Scholar, including studies in English on the pediatric population, without time restrictions. Results: Six articles, published between 2016 and 2021, were included in the systematic review. Sedation effectiveness was high across the studies, except for one study; 3 μg/kg was the dosing most often used. A comparison group was present in three studies, with oral chloral hydrate as the drug of comparison. Adverse effects were rarely reported. Conclusion: This systematic review showed how IN DEX can represent an adequate sedative for children undergoing ABR testing; larger and more rigorous trials are warranted in order to recommend its systematic utilization.
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spelling pubmed-88725912022-02-25 Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature Marra, Pasquale Di Stadio, Arianna Colacurcio, Vito Scarpa, Alfonso La Mantia, Ignazio Salzano, Francesco Antonio De Luca, Pietro Healthcare (Basel) Systematic Review Background: Intranasal dexmedetomidine (IN DEX) is a relatively new sedative agent with supporting evidence on its efficacy and safety, which can be used for procedural sedation in children, and could have a major role in auditory brainstem response testing, especially in the case of non-cooperative children. The goal of this systematic review is to assess the role of IN DEX in ABR testing, evaluating the reported protocol, potential, and limits. Methods: We performed a comprehensive search strategy on PubMed, Scopus, and Google Scholar, including studies in English on the pediatric population, without time restrictions. Results: Six articles, published between 2016 and 2021, were included in the systematic review. Sedation effectiveness was high across the studies, except for one study; 3 μg/kg was the dosing most often used. A comparison group was present in three studies, with oral chloral hydrate as the drug of comparison. Adverse effects were rarely reported. Conclusion: This systematic review showed how IN DEX can represent an adequate sedative for children undergoing ABR testing; larger and more rigorous trials are warranted in order to recommend its systematic utilization. MDPI 2022-02-01 /pmc/articles/PMC8872591/ /pubmed/35206901 http://dx.doi.org/10.3390/healthcare10020287 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Marra, Pasquale
Di Stadio, Arianna
Colacurcio, Vito
Scarpa, Alfonso
La Mantia, Ignazio
Salzano, Francesco Antonio
De Luca, Pietro
Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature
title Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature
title_full Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature
title_fullStr Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature
title_full_unstemmed Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature
title_short Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature
title_sort sedation with intranasal dexmedetomidine in the pediatric population for auditory brainstem response testing: review of the existing literature
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872591/
https://www.ncbi.nlm.nih.gov/pubmed/35206901
http://dx.doi.org/10.3390/healthcare10020287
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