Cargando…

The m(6)A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay

The role of N6-methyladenosine (m(6)A) modifications has increasingly been associated with a diverse set of roles in modulating viruses and influencing the outcomes of viral infection. Here, we report that the landscape of m(6)A deposition is drastically shifted during Kaposi’s sarcoma–associated he...

Descripción completa

Detalles Bibliográficos
Autores principales:	Macveigh-Fierro, Daniel, Cicerchia, Angelina, Cadorette, Ashley, Sharma, Vasudha, Muller, Mandy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872733/ https://www.ncbi.nlm.nih.gov/pubmed/35177478 http://dx.doi.org/10.1073/pnas.2116662119

Ejemplares similares

Stealing the Show: KSHV Hijacks Host RNA Regulatory Pathways to Promote Infection
por: Macveigh-Fierro, Daniel, et al.
Publicado: (2020)

The KSHV ORF20 Protein Interacts with the Viral Processivity Factor ORF59 and Promotes Viral Reactivation
por: Hoffman, D., et al.
Publicado: (2021)

Fated for decay: RNA elements targeted by viral endonucleases
por: Rodriguez, William, et al.
Publicado: (2021)

KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence
por: Juillard, Franceline, et al.
Publicado: (2020)

Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases
por: Yan, Huaqing, et al.
Publicado: (2022)

Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export
por: Qiao, Yulong, et al.
Publicado: (2023)

RNA N(6)-methyladenosine reader YTHDC1 is essential for TGF-beta-mediated metastasis of triple negative breast cancer
por: Tan, Brandon, et al.
Publicado: (2022)

Pathogenic variants in the human m(6)A reader YTHDC2 are associated with primary ovarian insufficiency
por: McGlacken-Byrne, Sinéad M., et al.
Publicado: (2022)

m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin
por: Liang, Diefei, et al.
Publicado: (2021)

The m6A RNA Modification Quantity and the Prognostic Effect of Reader YTHDC2 in Colorectal Cancer
por: Liu, Tianyu, et al.
Publicado: (2022)

Crystal structure of a KSHV–SOX–DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff
por: Bagnéris, Claire, et al.
Publicado: (2011)

Depletion of m(6)A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin
por: Gao, Siyun, et al.
Publicado: (2021)

Nuclear m(6)A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
por: Kasowitz, Seth D., et al.
Publicado: (2018)

N(6)-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication
por: Zhu, Yinxing, et al.
Publicado: (2023)

The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline
por: Bailey, Alexis S, et al.
Publicado: (2017)

The m(6)A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′–3′ exoribonuclease XRN1
por: Kretschmer, Jens, et al.
Publicado: (2018)

Multiple Phosphorylations of SR Protein SRSF3 and Its Binding to m(6)A Reader YTHDC1 in Human Cells
por: Tatsuno, Takanori, et al.
Publicado: (2022)

The m(6)A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs
por: Dattilo, Dario, et al.
Publicado: (2023)

YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs
por: Roundtree, Ian A, et al.
Publicado: (2017)

Nuclear m(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos
por: Chen, Chuan, et al.
Publicado: (2021)

The N6-methyladenosine reader protein YTHDC2 promotes gastric cancer progression via enhancing YAP mRNA translation
por: Yuan, Wei, et al.
Publicado: (2021)

The Role of Bacteria in KSHV Infection and KSHV-Induced Cancers
por: Markazi, Ashley, et al.
Publicado: (2021)

Downregulation of m(6)A reader YTHDC2 promotes tumor progression and predicts poor prognosis in non‐small cell lung cancer
por: Sun, Shulei, et al.
Publicado: (2020)

The m(6)A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function
por: Ma, Lifang, et al.
Publicado: (2020)

The m6A reader protein YTHDC2 is a potential biomarker and associated with immune infiltration in head and neck squamous cell carcinoma
por: Li, Yang, et al.
Publicado: (2020)

Correction to: Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos
por: Chen, Chuan, et al.
Publicado: (2021)

ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2
por: Jain, Devanshi, et al.
Publicado: (2018)

Structural effects of m(6)A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1
por: Jones, Alisha N, et al.
Publicado: (2022)

Downregulation of m(6)A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway
por: Wang, Jin, et al.
Publicado: (2021)

Nuclear Aurora kinase A switches m(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4
por: Li, SiSi, et al.
Publicado: (2022)

A potassium-chloride co-transporter promotes tumor progression and castration resistance of prostate cancer through m(6)A reader YTHDC1
por: Yuan, Shuai, et al.
Publicado: (2023)

The m6A reader YTHDC1-mediated lncRNA CTBP1-AS2 m6A modification accelerates cholangiocarcinoma progression
por: Jin, Zhe, et al.
Publicado: (2023)

The m6A reader YTHDC1 regulates muscle stem cell proliferation via PI4K–Akt–mTOR signalling
por: Liu, Jin, et al.
Publicado: (2023)

YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis
por: Liu, Rong, et al.
Publicado: (2021)

KSHV SOX mediated host shutoff: the molecular mechanism underlying mRNA transcript processing
por: Lee, Hyunah, et al.
Publicado: (2017)

m(6)A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis
por: He, Jun-Ju, et al.
Publicado: (2020)

MLL1 is regulated by KSHV LANA and is important for virus latency
por: Tan, Min, et al.
Publicado: (2021)

KSHV LANA—The Master Regulator of KSHV Latency
por: Uppal, Timsy, et al.
Publicado: (2014)

Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis
por: Wang, Xiaogang, et al.
Publicado: (2023)

Structural basis of higher order oligomerization of KSHV inhibitor of cGAS
por: Bhowmik, Debipreeta, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3st1a1urj6o4o81ju325tsmako