Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability

Cancer metabolism, including in mitochondria, is a disease hallmark and therapeutic target, but its regulation is poorly understood. Here, we show that many human tumors have heterogeneous and often reduced levels of Mic60, or Mitofilin, an essential scaffold of mitochondrial structure. Despite a ca...

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Detalles Bibliográficos
Autores principales: Ghosh, Jagadish C., Perego, Michela, Agarwal, Ekta, Bertolini, Irene, Wang, Yuan, Goldman, Aaron R., Tang, Hsin-Yao, Kossenkov, Andrew V., Landis, Catherine J., Languino, Lucia R., Plow, Edward F., Morotti, Annamaria, Ottobrini, Luisa, Locatelli, Marco, Speicher, David W., Caino, M. Cecilia, Cassel, Joel, Salvino, Joseph M., Robert, Marie E., Vaira, Valentina, Altieri, Dario C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872753/
https://www.ncbi.nlm.nih.gov/pubmed/35177476
http://dx.doi.org/10.1073/pnas.2115624119

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