Network modeling predicts personalized gene expression and drug responses in valve myofibroblasts cultured with patient sera

Aortic valve stenosis (AVS) patients experience pathogenic valve leaflet stiffening due to excessive extracellular matrix (ECM) remodeling. Numerous microenvironmental cues influence pathogenic expression of ECM remodeling genes in tissue-resident valvular myofibroblasts, and the regulation of compl...

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Detalles Bibliográficos
Autores principales: Rogers, Jesse D., Aguado, Brian A., Watts, Kelsey M., Anseth, Kristi S., Richardson, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872767/
https://www.ncbi.nlm.nih.gov/pubmed/35181609
http://dx.doi.org/10.1073/pnas.2117323119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872767/
https://www.ncbi.nlm.nih.gov/pubmed/35181609
http://dx.doi.org/10.1073/pnas.2117323119

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