Cargando…
Network modeling predicts personalized gene expression and drug responses in valve myofibroblasts cultured with patient sera
Aortic valve stenosis (AVS) patients experience pathogenic valve leaflet stiffening due to excessive extracellular matrix (ECM) remodeling. Numerous microenvironmental cues influence pathogenic expression of ECM remodeling genes in tissue-resident valvular myofibroblasts, and the regulation of compl...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872767/ https://www.ncbi.nlm.nih.gov/pubmed/35181609 http://dx.doi.org/10.1073/pnas.2117323119 |