Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection

Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing virus control versus immune-mediated pathologies, and have been successfully employed for the treatment of viral diseases. Humans express 12 IFN-alpha (α) subtypes, which activate downstream signaling...

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Detalles Bibliográficos
Autores principales: Schuhenn, Jonas, Meister, Toni Luise, Todt, Daniel, Bracht, Thilo, Schork, Karin, Billaud, Jean-Noel, Elsner, Carina, Heinen, Natalie, Karakoese, Zehra, Haid, Sibylle, Kumar, Sriram, Brunotte, Linda, Eisenacher, Martin, Di, Yunyun, Lew, Jocelyne, Falzarano, Darryl, Chen, Jieliang, Yuan, Zhenghong, Pietschmann, Thomas, Wiegmann, Bettina, Uebner, Hendrik, Taube, Christian, Le-Trilling, Vu Thuy Khanh, Trilling, Mirko, Krawczyk, Adalbert, Ludwig, Stephan, Sitek, Barbara, Steinmann, Eike, Dittmer, Ulf, Lavender, Kerry J., Sutter, Kathrin, Pfaender, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872780/
https://www.ncbi.nlm.nih.gov/pubmed/35131898
http://dx.doi.org/10.1073/pnas.2111600119

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