Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections

Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel therapeutics. The CRISPR-Cas9 system has been recently proposed as a potential therapeutic tool for the treatment of viral...

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Autores principales: Najafi, Sajad, Tan, Shing Cheng, Aghamiri, Shahin, Raee, Pourya, Ebrahimi, Zahra, Jahromi, Zahra Kargar, Rahmati, Yazdan, Sadri Nahand, Javid, Piroozmand, Ahmad, Jajarmi, Vahid, Mirzaei, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Masson SAS. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872819/
https://www.ncbi.nlm.nih.gov/pubmed/35228065
http://dx.doi.org/10.1016/j.biopha.2022.112743
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author Najafi, Sajad
Tan, Shing Cheng
Aghamiri, Shahin
Raee, Pourya
Ebrahimi, Zahra
Jahromi, Zahra Kargar
Rahmati, Yazdan
Sadri Nahand, Javid
Piroozmand, Ahmad
Jajarmi, Vahid
Mirzaei, Hamed
author_facet Najafi, Sajad
Tan, Shing Cheng
Aghamiri, Shahin
Raee, Pourya
Ebrahimi, Zahra
Jahromi, Zahra Kargar
Rahmati, Yazdan
Sadri Nahand, Javid
Piroozmand, Ahmad
Jajarmi, Vahid
Mirzaei, Hamed
author_sort Najafi, Sajad
collection PubMed
description Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel therapeutics. The CRISPR-Cas9 system has been recently proposed as a potential therapeutic tool for the treatment of viral diseases. Here, we review the research progress in the use of CRISPR-Cas technology for treating viral infections, as well as the strategies for improving the delivery of this gene-editing tool in vivo. Key challenges that hinder the widespread clinical application of CRISPR-Cas9 technology are also discussed, and several possible directions for future research are proposed.
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spelling pubmed-88728192022-02-25 Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections Najafi, Sajad Tan, Shing Cheng Aghamiri, Shahin Raee, Pourya Ebrahimi, Zahra Jahromi, Zahra Kargar Rahmati, Yazdan Sadri Nahand, Javid Piroozmand, Ahmad Jajarmi, Vahid Mirzaei, Hamed Biomed Pharmacother Review Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel therapeutics. The CRISPR-Cas9 system has been recently proposed as a potential therapeutic tool for the treatment of viral diseases. Here, we review the research progress in the use of CRISPR-Cas technology for treating viral infections, as well as the strategies for improving the delivery of this gene-editing tool in vivo. Key challenges that hinder the widespread clinical application of CRISPR-Cas9 technology are also discussed, and several possible directions for future research are proposed. The Author(s). Published by Elsevier Masson SAS. 2022-04 2022-02-25 /pmc/articles/PMC8872819/ /pubmed/35228065 http://dx.doi.org/10.1016/j.biopha.2022.112743 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Najafi, Sajad
Tan, Shing Cheng
Aghamiri, Shahin
Raee, Pourya
Ebrahimi, Zahra
Jahromi, Zahra Kargar
Rahmati, Yazdan
Sadri Nahand, Javid
Piroozmand, Ahmad
Jajarmi, Vahid
Mirzaei, Hamed
Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections
title Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections
title_full Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections
title_fullStr Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections
title_full_unstemmed Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections
title_short Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections
title_sort therapeutic potentials of crispr-cas genome editing technology in human viral infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872819/
https://www.ncbi.nlm.nih.gov/pubmed/35228065
http://dx.doi.org/10.1016/j.biopha.2022.112743
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