Count on us: T cells in SARS-CoV-2 infection and vaccination

Robust T cell responses have been associated with milder outcomes in many infections. T cells also establish long-term memory pools and, as they are predominantly directed toward epitopes encompassing conserved peptides, can respond to SARS-CoV-2 variants, including Omicron. Here, we discuss epitope...

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Detalles Bibliográficos
Autores principales: Kedzierska, Katherine, Thomas, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872824/
https://www.ncbi.nlm.nih.gov/pubmed/35474748
http://dx.doi.org/10.1016/j.xcrm.2022.100562
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author Kedzierska, Katherine
Thomas, Paul G.
author_facet Kedzierska, Katherine
Thomas, Paul G.
author_sort Kedzierska, Katherine
collection PubMed
description Robust T cell responses have been associated with milder outcomes in many infections. T cells also establish long-term memory pools and, as they are predominantly directed toward epitopes encompassing conserved peptides, can respond to SARS-CoV-2 variants, including Omicron. Here, we discuss epitope-specific CD8(+) and CD4(+) T cell responses toward SARS-CoV-2 infection and vaccination, their subsequent persistence into long-term memory, and ongoing work to determine their role in limiting disease severity.
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spelling pubmed-88728242022-02-25 Count on us: T cells in SARS-CoV-2 infection and vaccination Kedzierska, Katherine Thomas, Paul G. Cell Rep Med Minireview Robust T cell responses have been associated with milder outcomes in many infections. T cells also establish long-term memory pools and, as they are predominantly directed toward epitopes encompassing conserved peptides, can respond to SARS-CoV-2 variants, including Omicron. Here, we discuss epitope-specific CD8(+) and CD4(+) T cell responses toward SARS-CoV-2 infection and vaccination, their subsequent persistence into long-term memory, and ongoing work to determine their role in limiting disease severity. Elsevier 2022-02-25 /pmc/articles/PMC8872824/ /pubmed/35474748 http://dx.doi.org/10.1016/j.xcrm.2022.100562 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Minireview
Kedzierska, Katherine
Thomas, Paul G.
Count on us: T cells in SARS-CoV-2 infection and vaccination
title Count on us: T cells in SARS-CoV-2 infection and vaccination
title_full Count on us: T cells in SARS-CoV-2 infection and vaccination
title_fullStr Count on us: T cells in SARS-CoV-2 infection and vaccination
title_full_unstemmed Count on us: T cells in SARS-CoV-2 infection and vaccination
title_short Count on us: T cells in SARS-CoV-2 infection and vaccination
title_sort count on us: t cells in sars-cov-2 infection and vaccination
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872824/
https://www.ncbi.nlm.nih.gov/pubmed/35474748
http://dx.doi.org/10.1016/j.xcrm.2022.100562
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