Cargando…
Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure
Most patients infected with SARS-CoV-2 (COVID-19) experience mild, non-specific symptoms, but many develop severe symptoms associated with an excessive inflammatory response. Elevated plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) provide early warning of progressi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872836/ https://www.ncbi.nlm.nih.gov/pubmed/35474750 http://dx.doi.org/10.1016/j.xcrm.2022.100560 |
_version_ | 1784657334571630592 |
---|---|
author | Giamarellos-Bourboulis, Evangelos J. Poulakou, Garyfallia de Nooijer, Aline Milionis, Haralampos Metallidis, Simeon Ploumidis, Michalis Grigoropoulou, Pinelopi Rapti, Aggeliki Segala, Francesco Vladimiro Balis, Evangelos Giannitsioti, Efthymia Rodari, Paola Kainis, Ilias Alexiou, Zoi Focà, Emanuele Lucio, Brollo Rovina, Nikoletta Scorzolini, Laura Dafni, Maria Ioannou, Sofia Tomelleri, Alessandro Dimakou, Katerina Tzatzagou, Glykeria Chini, Maria Bassetti, Matteo Trakatelli, Christina Tsoukalas, George Selmi, Carlo Samaras, Charilaos Saridaki, Maria Pyrpasopoulou, Athina Kaldara, Elisabeth Papanikolaou, Ilias Argyraki, Aikaterini Akinosoglou, Karolina Koupetori, Marina Panagopoulos, Periklis Dalekos, George N. Netea, Mihai G. |
author_facet | Giamarellos-Bourboulis, Evangelos J. Poulakou, Garyfallia de Nooijer, Aline Milionis, Haralampos Metallidis, Simeon Ploumidis, Michalis Grigoropoulou, Pinelopi Rapti, Aggeliki Segala, Francesco Vladimiro Balis, Evangelos Giannitsioti, Efthymia Rodari, Paola Kainis, Ilias Alexiou, Zoi Focà, Emanuele Lucio, Brollo Rovina, Nikoletta Scorzolini, Laura Dafni, Maria Ioannou, Sofia Tomelleri, Alessandro Dimakou, Katerina Tzatzagou, Glykeria Chini, Maria Bassetti, Matteo Trakatelli, Christina Tsoukalas, George Selmi, Carlo Samaras, Charilaos Saridaki, Maria Pyrpasopoulou, Athina Kaldara, Elisabeth Papanikolaou, Ilias Argyraki, Aikaterini Akinosoglou, Karolina Koupetori, Marina Panagopoulos, Periklis Dalekos, George N. Netea, Mihai G. |
author_sort | Giamarellos-Bourboulis, Evangelos J. |
collection | PubMed |
description | Most patients infected with SARS-CoV-2 (COVID-19) experience mild, non-specific symptoms, but many develop severe symptoms associated with an excessive inflammatory response. Elevated plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) provide early warning of progression to severe respiratory failure (SRF) or death, but access to suPAR testing may be limited. The Severe COvid Prediction Estimate (SCOPE) score, derived from circulating concentrations of C-reactive protein, D- dimers, interleukin-6, and ferritin among patients not receiving non-invasive or invasive mechanical ventilation during the SAVE-MORE study, offers predictive accuracy for progression to SRF or death within 14 days comparable to that of a suPAR concentration of ≥6 ng/mL (area under receiver operator characteristic curve 0.81 for both). The SCOPE score is validated in two similar independent cohorts. A SCOPE score of 6 or more is an alternative to suPAR for predicting progression to SRF or death within 14 days of hospital admission for pneumonia, and it can be used to guide treatment decisions. |
format | Online Article Text |
id | pubmed-8872836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88728362022-02-25 Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure Giamarellos-Bourboulis, Evangelos J. Poulakou, Garyfallia de Nooijer, Aline Milionis, Haralampos Metallidis, Simeon Ploumidis, Michalis Grigoropoulou, Pinelopi Rapti, Aggeliki Segala, Francesco Vladimiro Balis, Evangelos Giannitsioti, Efthymia Rodari, Paola Kainis, Ilias Alexiou, Zoi Focà, Emanuele Lucio, Brollo Rovina, Nikoletta Scorzolini, Laura Dafni, Maria Ioannou, Sofia Tomelleri, Alessandro Dimakou, Katerina Tzatzagou, Glykeria Chini, Maria Bassetti, Matteo Trakatelli, Christina Tsoukalas, George Selmi, Carlo Samaras, Charilaos Saridaki, Maria Pyrpasopoulou, Athina Kaldara, Elisabeth Papanikolaou, Ilias Argyraki, Aikaterini Akinosoglou, Karolina Koupetori, Marina Panagopoulos, Periklis Dalekos, George N. Netea, Mihai G. Cell Rep Med Article Most patients infected with SARS-CoV-2 (COVID-19) experience mild, non-specific symptoms, but many develop severe symptoms associated with an excessive inflammatory response. Elevated plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) provide early warning of progression to severe respiratory failure (SRF) or death, but access to suPAR testing may be limited. The Severe COvid Prediction Estimate (SCOPE) score, derived from circulating concentrations of C-reactive protein, D- dimers, interleukin-6, and ferritin among patients not receiving non-invasive or invasive mechanical ventilation during the SAVE-MORE study, offers predictive accuracy for progression to SRF or death within 14 days comparable to that of a suPAR concentration of ≥6 ng/mL (area under receiver operator characteristic curve 0.81 for both). The SCOPE score is validated in two similar independent cohorts. A SCOPE score of 6 or more is an alternative to suPAR for predicting progression to SRF or death within 14 days of hospital admission for pneumonia, and it can be used to guide treatment decisions. Elsevier 2022-02-25 /pmc/articles/PMC8872836/ /pubmed/35474750 http://dx.doi.org/10.1016/j.xcrm.2022.100560 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Giamarellos-Bourboulis, Evangelos J. Poulakou, Garyfallia de Nooijer, Aline Milionis, Haralampos Metallidis, Simeon Ploumidis, Michalis Grigoropoulou, Pinelopi Rapti, Aggeliki Segala, Francesco Vladimiro Balis, Evangelos Giannitsioti, Efthymia Rodari, Paola Kainis, Ilias Alexiou, Zoi Focà, Emanuele Lucio, Brollo Rovina, Nikoletta Scorzolini, Laura Dafni, Maria Ioannou, Sofia Tomelleri, Alessandro Dimakou, Katerina Tzatzagou, Glykeria Chini, Maria Bassetti, Matteo Trakatelli, Christina Tsoukalas, George Selmi, Carlo Samaras, Charilaos Saridaki, Maria Pyrpasopoulou, Athina Kaldara, Elisabeth Papanikolaou, Ilias Argyraki, Aikaterini Akinosoglou, Karolina Koupetori, Marina Panagopoulos, Periklis Dalekos, George N. Netea, Mihai G. Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure |
title | Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure |
title_full | Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure |
title_fullStr | Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure |
title_full_unstemmed | Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure |
title_short | Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure |
title_sort | development and validation of scope score: a clinical score to predict covid-19 pneumonia progression to severe respiratory failure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872836/ https://www.ncbi.nlm.nih.gov/pubmed/35474750 http://dx.doi.org/10.1016/j.xcrm.2022.100560 |
work_keys_str_mv | AT giamarellosbourboulisevangelosj developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT poulakougaryfallia developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT denooijeraline developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT milionisharalampos developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT metallidissimeon developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT ploumidismichalis developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT grigoropouloupinelopi developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT raptiaggeliki developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT segalafrancescovladimiro developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT balisevangelos developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT giannitsiotiefthymia developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT rodaripaola developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT kainisilias developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT alexiouzoi developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT focaemanuele developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT luciobrollo developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT rovinanikoletta developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT scorzolinilaura developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT dafnimaria developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT ioannousofia developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT tomellerialessandro developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT dimakoukaterina developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT tzatzagouglykeria developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT chinimaria developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT bassettimatteo developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT trakatellichristina developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT tsoukalasgeorge developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT selmicarlo developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT samarascharilaos developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT saridakimaria developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT pyrpasopoulouathina developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT kaldaraelisabeth developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT papanikolaouilias developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT argyrakiaikaterini developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT akinosogloukarolina developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT koupetorimarina developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT panagopoulosperiklis developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT dalekosgeorgen developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure AT neteamihaig developmentandvalidationofscopescoreaclinicalscoretopredictcovid19pneumoniaprogressiontosevererespiratoryfailure |