Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Comprehensive determination of the extent of drug transport across the region-specific blood–brain barrier (BBB) is a major challenge in preclinical studies. Multiple approaches are needed to determine the regional free (unbound) drug concentration at which a drug engages with its therapeutic target...

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Detalles Bibliográficos
Autores principales: Luptáková, Dominika, Vallianatou, Theodosia, Nilsson, Anna, Shariatgorji, Reza, Hammarlund-Udenaes, Margareta, Loryan, Irena, Andrén, Per E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872980/
https://www.ncbi.nlm.nih.gov/pubmed/34480089
http://dx.doi.org/10.1038/s41380-021-01267-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872980/
https://www.ncbi.nlm.nih.gov/pubmed/34480089
http://dx.doi.org/10.1038/s41380-021-01267-y

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