Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism

Reciprocal deletion and duplication of the 16p11.2 region is the most common copy number variation (CNV) associated with autism spectrum disorders. We generated cortical organoids from skin fibroblasts of patients with 16p11.2 CNV to investigate impacted neurodevelopmental processes. We show that or...

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Detalles Bibliográficos
Autores principales: Urresti, Jorge, Zhang, Pan, Moran-Losada, Patricia, Yu, Nam-Kyung, Negraes, Priscilla D., Trujillo, Cleber A., Antaki, Danny, Amar, Megha, Chau, Kevin, Pramod, Akula Bala, Diedrich, Jolene, Tejwani, Leon, Romero, Sarah, Sebat, Jonathan, Yates III, John R., Muotri, Alysson R., Iakoucheva, Lilia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873019/
https://www.ncbi.nlm.nih.gov/pubmed/34433918
http://dx.doi.org/10.1038/s41380-021-01243-6

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