Targeting ferroptosis in acute kidney injury

Acute kidney injury (AKI) is a major public health problem with high incidence and mortality. As a form of programmed cell death (PCD), ferroptosis could be considered as a process of iron accumulation and enhanced lipid peroxidation. Recently, the fundamental roles of ferroptosis in AKI have attrac...

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Autores principales: Ni, Lihua, Yuan, Cheng, Wu, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873203/
https://www.ncbi.nlm.nih.gov/pubmed/35210424
http://dx.doi.org/10.1038/s41419-022-04628-9
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author Ni, Lihua
Yuan, Cheng
Wu, Xiaoyan
author_facet Ni, Lihua
Yuan, Cheng
Wu, Xiaoyan
author_sort Ni, Lihua
collection PubMed
description Acute kidney injury (AKI) is a major public health problem with high incidence and mortality. As a form of programmed cell death (PCD), ferroptosis could be considered as a process of iron accumulation and enhanced lipid peroxidation. Recently, the fundamental roles of ferroptosis in AKI have attracted much attention. The network mechanism of ferroptosis in AKI and its roles in the AKI to chronic kidney disease (CKD) transition is complicated and multifactorial. Strategies targeting ferroptosis show great potential. Here, we review the research progress on ferroptosis and its participation in AKI. We hope that this work will provide clues for further studies of ferroptosis in AKI.
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spelling pubmed-88732032022-03-17 Targeting ferroptosis in acute kidney injury Ni, Lihua Yuan, Cheng Wu, Xiaoyan Cell Death Dis Article Acute kidney injury (AKI) is a major public health problem with high incidence and mortality. As a form of programmed cell death (PCD), ferroptosis could be considered as a process of iron accumulation and enhanced lipid peroxidation. Recently, the fundamental roles of ferroptosis in AKI have attracted much attention. The network mechanism of ferroptosis in AKI and its roles in the AKI to chronic kidney disease (CKD) transition is complicated and multifactorial. Strategies targeting ferroptosis show great potential. Here, we review the research progress on ferroptosis and its participation in AKI. We hope that this work will provide clues for further studies of ferroptosis in AKI. Nature Publishing Group UK 2022-02-24 /pmc/articles/PMC8873203/ /pubmed/35210424 http://dx.doi.org/10.1038/s41419-022-04628-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ni, Lihua
Yuan, Cheng
Wu, Xiaoyan
Targeting ferroptosis in acute kidney injury
title Targeting ferroptosis in acute kidney injury
title_full Targeting ferroptosis in acute kidney injury
title_fullStr Targeting ferroptosis in acute kidney injury
title_full_unstemmed Targeting ferroptosis in acute kidney injury
title_short Targeting ferroptosis in acute kidney injury
title_sort targeting ferroptosis in acute kidney injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873203/
https://www.ncbi.nlm.nih.gov/pubmed/35210424
http://dx.doi.org/10.1038/s41419-022-04628-9
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