An amiloride derivative is active against the F(1)F(o)-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis

Increasing antimicrobial resistance compels the search for next-generation inhibitors with differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium tuberculosis has been clinically validated as a promising new drug target for combatting drug-resistant strains of...

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Detalles Bibliográficos
Autores principales: Hards, Kiel, Cheung, Chen-Yi, Waller, Natalie, Adolph, Cara, Keighley, Laura, Tee, Zhi Shean, Harold, Liam K., Menorca, Ayana, Bujaroski, Richard S., Buckley, Benjamin J., Tyndall, Joel D. A., McNeil, Matthew B., Rhee, Kyu Y., Opel-Reading, Helen K., Krause, Kurt, Preiss, Laura, Langer, Julian D., Meier, Thomas, Hasenoehrl, Erik J., Berney, Michael, Kelso, Michael J., Cook, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873251/
https://www.ncbi.nlm.nih.gov/pubmed/35210534
http://dx.doi.org/10.1038/s42003-022-03110-8

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