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Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits
Sensory processing in the cortex adapts to the history of stimulation but the mechanisms are not understood. Imaging the primary visual cortex of mice we find here that an increase in stimulus contrast is not followed by a simple decrease in gain of pyramidal cells; as many cells increase gain to im...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873261/ https://www.ncbi.nlm.nih.gov/pubmed/35210417 http://dx.doi.org/10.1038/s41467-022-28635-8 |
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author | Heintz, Tristan G. Hinojosa, Antonio J. Dominiak, Sina E. Lagnado, Leon |
author_facet | Heintz, Tristan G. Hinojosa, Antonio J. Dominiak, Sina E. Lagnado, Leon |
author_sort | Heintz, Tristan G. |
collection | PubMed |
description | Sensory processing in the cortex adapts to the history of stimulation but the mechanisms are not understood. Imaging the primary visual cortex of mice we find here that an increase in stimulus contrast is not followed by a simple decrease in gain of pyramidal cells; as many cells increase gain to improve detection of a subsequent decrease in contrast. Depressing and sensitizing forms of adaptation also occur in different types of interneurons (PV, SST and VIP) and the net effect within individual pyramidal cells reflects the balance of PV inputs, driving depression, and a subset of SST interneurons driving sensitization. Changes in internal state associated with locomotion increase gain across the population of pyramidal cells while maintaining the balance between these opposite forms of plasticity, consistent with activation of both VIP->SST and SST->PV disinhibitory pathways. These results reveal how different inhibitory microcircuits adjust the gain of pyramidal cells signalling changes in stimulus strength. |
format | Online Article Text |
id | pubmed-8873261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-88732612022-03-17 Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits Heintz, Tristan G. Hinojosa, Antonio J. Dominiak, Sina E. Lagnado, Leon Nat Commun Article Sensory processing in the cortex adapts to the history of stimulation but the mechanisms are not understood. Imaging the primary visual cortex of mice we find here that an increase in stimulus contrast is not followed by a simple decrease in gain of pyramidal cells; as many cells increase gain to improve detection of a subsequent decrease in contrast. Depressing and sensitizing forms of adaptation also occur in different types of interneurons (PV, SST and VIP) and the net effect within individual pyramidal cells reflects the balance of PV inputs, driving depression, and a subset of SST interneurons driving sensitization. Changes in internal state associated with locomotion increase gain across the population of pyramidal cells while maintaining the balance between these opposite forms of plasticity, consistent with activation of both VIP->SST and SST->PV disinhibitory pathways. These results reveal how different inhibitory microcircuits adjust the gain of pyramidal cells signalling changes in stimulus strength. Nature Publishing Group UK 2022-02-24 /pmc/articles/PMC8873261/ /pubmed/35210417 http://dx.doi.org/10.1038/s41467-022-28635-8 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Heintz, Tristan G. Hinojosa, Antonio J. Dominiak, Sina E. Lagnado, Leon Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits |
title | Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits |
title_full | Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits |
title_fullStr | Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits |
title_full_unstemmed | Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits |
title_short | Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits |
title_sort | opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873261/ https://www.ncbi.nlm.nih.gov/pubmed/35210417 http://dx.doi.org/10.1038/s41467-022-28635-8 |
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