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Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits

Sensory processing in the cortex adapts to the history of stimulation but the mechanisms are not understood. Imaging the primary visual cortex of mice we find here that an increase in stimulus contrast is not followed by a simple decrease in gain of pyramidal cells; as many cells increase gain to im...

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Autores principales: Heintz, Tristan G., Hinojosa, Antonio J., Dominiak, Sina E., Lagnado, Leon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873261/
https://www.ncbi.nlm.nih.gov/pubmed/35210417
http://dx.doi.org/10.1038/s41467-022-28635-8
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author Heintz, Tristan G.
Hinojosa, Antonio J.
Dominiak, Sina E.
Lagnado, Leon
author_facet Heintz, Tristan G.
Hinojosa, Antonio J.
Dominiak, Sina E.
Lagnado, Leon
author_sort Heintz, Tristan G.
collection PubMed
description Sensory processing in the cortex adapts to the history of stimulation but the mechanisms are not understood. Imaging the primary visual cortex of mice we find here that an increase in stimulus contrast is not followed by a simple decrease in gain of pyramidal cells; as many cells increase gain to improve detection of a subsequent decrease in contrast. Depressing and sensitizing forms of adaptation also occur in different types of interneurons (PV, SST and VIP) and the net effect within individual pyramidal cells reflects the balance of PV inputs, driving depression, and a subset of SST interneurons driving sensitization. Changes in internal state associated with locomotion increase gain across the population of pyramidal cells while maintaining the balance between these opposite forms of plasticity, consistent with activation of both VIP->SST and SST->PV disinhibitory pathways. These results reveal how different inhibitory microcircuits adjust the gain of pyramidal cells signalling changes in stimulus strength.
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spelling pubmed-88732612022-03-17 Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits Heintz, Tristan G. Hinojosa, Antonio J. Dominiak, Sina E. Lagnado, Leon Nat Commun Article Sensory processing in the cortex adapts to the history of stimulation but the mechanisms are not understood. Imaging the primary visual cortex of mice we find here that an increase in stimulus contrast is not followed by a simple decrease in gain of pyramidal cells; as many cells increase gain to improve detection of a subsequent decrease in contrast. Depressing and sensitizing forms of adaptation also occur in different types of interneurons (PV, SST and VIP) and the net effect within individual pyramidal cells reflects the balance of PV inputs, driving depression, and a subset of SST interneurons driving sensitization. Changes in internal state associated with locomotion increase gain across the population of pyramidal cells while maintaining the balance between these opposite forms of plasticity, consistent with activation of both VIP->SST and SST->PV disinhibitory pathways. These results reveal how different inhibitory microcircuits adjust the gain of pyramidal cells signalling changes in stimulus strength. Nature Publishing Group UK 2022-02-24 /pmc/articles/PMC8873261/ /pubmed/35210417 http://dx.doi.org/10.1038/s41467-022-28635-8 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Heintz, Tristan G.
Hinojosa, Antonio J.
Dominiak, Sina E.
Lagnado, Leon
Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits
title Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits
title_full Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits
title_fullStr Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits
title_full_unstemmed Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits
title_short Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits
title_sort opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873261/
https://www.ncbi.nlm.nih.gov/pubmed/35210417
http://dx.doi.org/10.1038/s41467-022-28635-8
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