The E3 ubiquitin ligase, FBXW5, promotes the migration and invasion of gastric cancer through the dysregulation of the Hippo pathway

F-box and WD repeat domain-containing 5 (FBXW5), with WD40 repeats, can bind to the PPxY sequence of the large tumor suppressor kinases 1/2 (LATS1/2) kinase domain, resulting in ubiquitination. Ubiquitination and the subsequent degradation of LATS1/2 abrogate the Hippo pathway and worsen gastric can...

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Detalles Bibliográficos
Autores principales: Yao, Yangyang, Liu, Zhen, Huang, Shanshan, Huang, Chunye, Cao, Yuan, Li, Li, Guo, Hui, Liu, Fenfen, Huang, Shipeng, Liao, Quan, He, Xin, Chen, Jun, Li, Junhe, Xiang, Xiaojun, Xiong, Jianping, Deng, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873275/
https://www.ncbi.nlm.nih.gov/pubmed/35210431
http://dx.doi.org/10.1038/s41420-022-00868-y

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