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Local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis

TGF-β1 is an important growth factor to promote the differentiation of T helper 17 (Th17) and regulatory T cells (Treg). The potential of TGF-β1 as therapeutic target in T cell-mediated diseases like rheumatoid arthritis (RA) is unclear. We investigated the effect of TGF-β1 inhibition on murine Th17...

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Detalles Bibliográficos
Autores principales:	Aarts, Joyce, van Caam, Arjan, Chen, Xinlai, Marijnissen, Renoud J., Helsen, Monique M., Walgreen, Birgitte, Vitters, Elly L., van de Loo, Fons A., van Lent, Peter L., van der Kraan, Peter M., Koenders, Marije I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873460/ https://www.ncbi.nlm.nih.gov/pubmed/35210510 http://dx.doi.org/10.1038/s41598-022-07075-w

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