Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease

Parkinson’s disease (PD) is clinically defined by the presence of the cardinal motor symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the substantia nigra pars compacta (SNpc). While SNpc neurons serve as the prototypical cell-type to study cellular vulnerability i...

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Detalles Bibliográficos
Autores principales: Matschke, Lina A., Komadowski, Marlene A., Stöhr, Annette, Lee, Bolam, Henrich, Martin T., Griesbach, Markus, Rinné, Susanne, Geibl, Fanni F., Chiu, Wei-Hua, Koprich, James B., Brotchie, Jonathan M., Kiper, Aytug K., Dolga, Amalia M., Oertel, Wolfgang H., Decher, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873463/
https://www.ncbi.nlm.nih.gov/pubmed/35210472
http://dx.doi.org/10.1038/s41598-022-06832-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873463/
https://www.ncbi.nlm.nih.gov/pubmed/35210472
http://dx.doi.org/10.1038/s41598-022-06832-1

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