Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Cytotoxic T lymphocytes (CTL) kill malignant and infected cells through the directed release of cytotoxic proteins into the immunological synapse (IS). The cytotoxic protein granzyme B (GzmB) is released in its soluble form or in supramolecular attack particles (SMAP). We utilize synaptobrevin2-mRFP...

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Detalles Bibliográficos
Autores principales: Chang, Hsin-Fang, Schirra, Claudia, Ninov, Momchil, Hahn, Ulrike, Ravichandran, Keerthana, Krause, Elmar, Becherer, Ute, Bálint, Štefan, Harkiolaki, Maria, Urlaub, Henning, Valitutti, Salvatore, Baldari, Cosima T., Dustin, Michael L., Jahn, Reinhard, Rettig, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873490/
https://www.ncbi.nlm.nih.gov/pubmed/35210420
http://dx.doi.org/10.1038/s41467-022-28596-y

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