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Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics

Clinical practice guidelines (CPGs) translate evidence into recommendations to improve patient care and outcomes. To provide an overview of schizophrenia CPGs, we conducted a systematic literature review of English-language CPGs and synthesized current recommendations for the acute and maintenance m...

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Autores principales: Correll, Christoph U., Martin, Amber, Patel, Charmi, Benson, Carmela, Goulding, Rebecca, Kern-Sliwa, Jennifer, Joshi, Kruti, Schiller, Emma, Kim, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873492/
https://www.ncbi.nlm.nih.gov/pubmed/35210430
http://dx.doi.org/10.1038/s41537-021-00192-x
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author Correll, Christoph U.
Martin, Amber
Patel, Charmi
Benson, Carmela
Goulding, Rebecca
Kern-Sliwa, Jennifer
Joshi, Kruti
Schiller, Emma
Kim, Edward
author_facet Correll, Christoph U.
Martin, Amber
Patel, Charmi
Benson, Carmela
Goulding, Rebecca
Kern-Sliwa, Jennifer
Joshi, Kruti
Schiller, Emma
Kim, Edward
author_sort Correll, Christoph U.
collection PubMed
description Clinical practice guidelines (CPGs) translate evidence into recommendations to improve patient care and outcomes. To provide an overview of schizophrenia CPGs, we conducted a systematic literature review of English-language CPGs and synthesized current recommendations for the acute and maintenance management with antipsychotics. Searches for schizophrenia CPGs were conducted in MEDLINE/Embase from 1/1/2004–12/19/2019 and in guideline websites until 06/01/2020. Of 19 CPGs, 17 (89.5%) commented on first-episode schizophrenia (FES), with all recommending antipsychotic monotherapy, but without agreement on preferred antipsychotic. Of 18 CPGs commenting on maintenance therapy, 10 (55.6%) made no recommendations on the appropriate maximum duration of maintenance therapy, noting instead individualization of care. Eighteen (94.7%) CPGs commented on long-acting injectable antipsychotics (LAIs), mainly in cases of nonadherence (77.8%), maintenance care (72.2%), or patient preference (66.7%), with 5 (27.8%) CPGs recommending LAIs for FES. For treatment-resistant schizophrenia, 15/15 CPGs recommended clozapine. Only 7/19 (38.8%) CPGs included a treatment algorithm.
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spelling pubmed-88734922022-03-17 Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics Correll, Christoph U. Martin, Amber Patel, Charmi Benson, Carmela Goulding, Rebecca Kern-Sliwa, Jennifer Joshi, Kruti Schiller, Emma Kim, Edward Schizophrenia (Heidelb) Article Clinical practice guidelines (CPGs) translate evidence into recommendations to improve patient care and outcomes. To provide an overview of schizophrenia CPGs, we conducted a systematic literature review of English-language CPGs and synthesized current recommendations for the acute and maintenance management with antipsychotics. Searches for schizophrenia CPGs were conducted in MEDLINE/Embase from 1/1/2004–12/19/2019 and in guideline websites until 06/01/2020. Of 19 CPGs, 17 (89.5%) commented on first-episode schizophrenia (FES), with all recommending antipsychotic monotherapy, but without agreement on preferred antipsychotic. Of 18 CPGs commenting on maintenance therapy, 10 (55.6%) made no recommendations on the appropriate maximum duration of maintenance therapy, noting instead individualization of care. Eighteen (94.7%) CPGs commented on long-acting injectable antipsychotics (LAIs), mainly in cases of nonadherence (77.8%), maintenance care (72.2%), or patient preference (66.7%), with 5 (27.8%) CPGs recommending LAIs for FES. For treatment-resistant schizophrenia, 15/15 CPGs recommended clozapine. Only 7/19 (38.8%) CPGs included a treatment algorithm. Nature Publishing Group UK 2022-02-24 /pmc/articles/PMC8873492/ /pubmed/35210430 http://dx.doi.org/10.1038/s41537-021-00192-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Correll, Christoph U.
Martin, Amber
Patel, Charmi
Benson, Carmela
Goulding, Rebecca
Kern-Sliwa, Jennifer
Joshi, Kruti
Schiller, Emma
Kim, Edward
Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics
title Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics
title_full Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics
title_fullStr Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics
title_full_unstemmed Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics
title_short Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics
title_sort systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873492/
https://www.ncbi.nlm.nih.gov/pubmed/35210430
http://dx.doi.org/10.1038/s41537-021-00192-x
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