SPINKs in Tumors: Potential Therapeutic Targets

The serine protease inhibitor Kazal type (SPINK) family includes SPINK1-14 and is the largest branch in the serine protease inhibitor family. SPINKs play an important role in pancreatic physiology and disease, sperm maturation and capacitation, Nager syndrome, inflammation and the skin barrier. Evid...

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Autores principales: Liao, Chengcheng, Wang, Qian, An, Jiaxing, Zhang, Minglin, Chen, Jie, Li, Xiaolan, Xiao, Linlin, Wang, Jiajia, Long, Qian, Liu, Jianguo, Guan, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873584/
https://www.ncbi.nlm.nih.gov/pubmed/35223512
http://dx.doi.org/10.3389/fonc.2022.833741
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author Liao, Chengcheng
Wang, Qian
An, Jiaxing
Zhang, Minglin
Chen, Jie
Li, Xiaolan
Xiao, Linlin
Wang, Jiajia
Long, Qian
Liu, Jianguo
Guan, Xiaoyan
author_facet Liao, Chengcheng
Wang, Qian
An, Jiaxing
Zhang, Minglin
Chen, Jie
Li, Xiaolan
Xiao, Linlin
Wang, Jiajia
Long, Qian
Liu, Jianguo
Guan, Xiaoyan
author_sort Liao, Chengcheng
collection PubMed
description The serine protease inhibitor Kazal type (SPINK) family includes SPINK1-14 and is the largest branch in the serine protease inhibitor family. SPINKs play an important role in pancreatic physiology and disease, sperm maturation and capacitation, Nager syndrome, inflammation and the skin barrier. Evidence shows that the unregulated expression of SPINK1, 2, 4, 5, 6, 7, and 13 is closely related to human tumors. Different SPINKs exhibit various regulatory modes in different tumors and can be used as tumor prognostic markers. This article reviews the role of SPINK1, 2, 4, 5, 6, 7, and 13 in different human cancer processes and helps to identify new cancer treatment targets.
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spelling pubmed-88735842022-02-26 SPINKs in Tumors: Potential Therapeutic Targets Liao, Chengcheng Wang, Qian An, Jiaxing Zhang, Minglin Chen, Jie Li, Xiaolan Xiao, Linlin Wang, Jiajia Long, Qian Liu, Jianguo Guan, Xiaoyan Front Oncol Oncology The serine protease inhibitor Kazal type (SPINK) family includes SPINK1-14 and is the largest branch in the serine protease inhibitor family. SPINKs play an important role in pancreatic physiology and disease, sperm maturation and capacitation, Nager syndrome, inflammation and the skin barrier. Evidence shows that the unregulated expression of SPINK1, 2, 4, 5, 6, 7, and 13 is closely related to human tumors. Different SPINKs exhibit various regulatory modes in different tumors and can be used as tumor prognostic markers. This article reviews the role of SPINK1, 2, 4, 5, 6, 7, and 13 in different human cancer processes and helps to identify new cancer treatment targets. Frontiers Media S.A. 2022-02-11 /pmc/articles/PMC8873584/ /pubmed/35223512 http://dx.doi.org/10.3389/fonc.2022.833741 Text en Copyright © 2022 Liao, Wang, An, Zhang, Chen, Li, Xiao, Wang, Long, Liu and Guan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liao, Chengcheng
Wang, Qian
An, Jiaxing
Zhang, Minglin
Chen, Jie
Li, Xiaolan
Xiao, Linlin
Wang, Jiajia
Long, Qian
Liu, Jianguo
Guan, Xiaoyan
SPINKs in Tumors: Potential Therapeutic Targets
title SPINKs in Tumors: Potential Therapeutic Targets
title_full SPINKs in Tumors: Potential Therapeutic Targets
title_fullStr SPINKs in Tumors: Potential Therapeutic Targets
title_full_unstemmed SPINKs in Tumors: Potential Therapeutic Targets
title_short SPINKs in Tumors: Potential Therapeutic Targets
title_sort spinks in tumors: potential therapeutic targets
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873584/
https://www.ncbi.nlm.nih.gov/pubmed/35223512
http://dx.doi.org/10.3389/fonc.2022.833741
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