Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-Cells

BACKGROUND & AIMS: Compelling evidence shows that glucagon-like peptide-1 (GLP-1) has a profound effect in restoring normoglycemia in type 2 diabetic patients by increasing pancreatic insulin secretion. Although L-cells are the primary source of circulating GLP-1, the current therapies do not ta...

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Detalles Bibliográficos
Autores principales: Mooli, Raja Gopal Reddy, Mukhi, Dhanunjay, Pasupulati, Anil K., Evers, Simon S., Sipula, Ian J., Jurczak, Michael, Seeley, Randy J., Shah, Yatrik M., Ramakrishnan, Sadeesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873605/
https://www.ncbi.nlm.nih.gov/pubmed/34902628
http://dx.doi.org/10.1016/j.jcmgh.2021.12.004

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