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Electrostatic Interactions between CSTF2 and pre-mRNA Drive Cleavage and Polyadenylation

Nascent pre-mRNA 3′-end cleavage and polyadenylation (C/P) involves numerous proteins that recognize multiple RNA elements. Human CSTF2 binds to a downstream U- or G/U-rich sequence through its RNA recognition motif (RRM) regulating C/P. We previously reported the only known disease-related CSTF2 RR...

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Detalles Bibliográficos
Autores principales:	Masoumzadeh, Elahe, Grozdanov, Petar N., Jetly, Anushka, MacDonald, Clinton C., Latham, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873925/ https://www.ncbi.nlm.nih.gov/pubmed/35090899 http://dx.doi.org/10.1016/j.bpj.2022.01.005

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