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Pre-COVID-19 Immunity to Common Cold Human Coronaviruses Induces a Recall-Type IgG Response to SARS-CoV-2 Antigens Without Cross-Neutralisation
The capacity of pre-existing immunity to human common coronaviruses (HCoV) to cross-protect against de novo COVID-19is yet unknown. In this work, we studied the sera of 175 COVID-19 patients, 76 healthy donors and 3 intravenous immunoglobulins (IVIG) batches. We found that most COVID-19 patients dev...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873934/ https://www.ncbi.nlm.nih.gov/pubmed/35222375 http://dx.doi.org/10.3389/fimmu.2022.790334 |
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author | Miyara, Makoto Saichi, Melissa Sterlin, Delphine Anna, François Marot, Stéphane Mathian, Alexis Atif, Mo Quentric, Paul Mohr, Audrey Claër, Laetitia Parizot, Christophe Dorgham, Karim Yssel, Hans Fadlallah, Jehane Chazal, Thibaut Haroche, Julien Luyt, Charles-Edouard Mayaux, Julien Beurton, Alexandra Benameur, Neila Boutolleau, David Burrel, Sonia de Alba, Sophia Mudumba, Sasi Hockett, Rick Gunn, Cary Charneau, Pierre Calvez, Vincent Marcelin, Anne-Geneviève Combes, Alain Demoule, Alexandre Amoura, Zahir Gorochov, Guy |
author_facet | Miyara, Makoto Saichi, Melissa Sterlin, Delphine Anna, François Marot, Stéphane Mathian, Alexis Atif, Mo Quentric, Paul Mohr, Audrey Claër, Laetitia Parizot, Christophe Dorgham, Karim Yssel, Hans Fadlallah, Jehane Chazal, Thibaut Haroche, Julien Luyt, Charles-Edouard Mayaux, Julien Beurton, Alexandra Benameur, Neila Boutolleau, David Burrel, Sonia de Alba, Sophia Mudumba, Sasi Hockett, Rick Gunn, Cary Charneau, Pierre Calvez, Vincent Marcelin, Anne-Geneviève Combes, Alain Demoule, Alexandre Amoura, Zahir Gorochov, Guy |
author_sort | Miyara, Makoto |
collection | PubMed |
description | The capacity of pre-existing immunity to human common coronaviruses (HCoV) to cross-protect against de novo COVID-19is yet unknown. In this work, we studied the sera of 175 COVID-19 patients, 76 healthy donors and 3 intravenous immunoglobulins (IVIG) batches. We found that most COVID-19 patients developed anti-SARS-CoV-2 IgG antibodies before IgM. Moreover, the capacity of their IgGs to react to beta-HCoV, was present in the early sera of most patients before the appearance of anti-SARS-CoV-2 IgG. This implied that a recall-type antibody response was generated. In comparison, the patients that mounted an anti-SARS-COV2 IgM response, prior to IgG responses had lower titres of anti-beta-HCoV IgG antibodies. This indicated that pre-existing immunity to beta-HCoV was conducive to the generation of memory type responses to SARS-COV-2. Finally, we also found that pre-COVID-19-era sera and IVIG cross-reacted with SARS-CoV-2 antigens without neutralising SARS-CoV-2 infectivity in vitro. Put together, these results indicate that whilst pre-existing immunity to HCoV is responsible for recall-type IgG responses to SARS-CoV-2, it does not lead to cross-protection against COVID-19. |
format | Online Article Text |
id | pubmed-8873934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88739342022-02-26 Pre-COVID-19 Immunity to Common Cold Human Coronaviruses Induces a Recall-Type IgG Response to SARS-CoV-2 Antigens Without Cross-Neutralisation Miyara, Makoto Saichi, Melissa Sterlin, Delphine Anna, François Marot, Stéphane Mathian, Alexis Atif, Mo Quentric, Paul Mohr, Audrey Claër, Laetitia Parizot, Christophe Dorgham, Karim Yssel, Hans Fadlallah, Jehane Chazal, Thibaut Haroche, Julien Luyt, Charles-Edouard Mayaux, Julien Beurton, Alexandra Benameur, Neila Boutolleau, David Burrel, Sonia de Alba, Sophia Mudumba, Sasi Hockett, Rick Gunn, Cary Charneau, Pierre Calvez, Vincent Marcelin, Anne-Geneviève Combes, Alain Demoule, Alexandre Amoura, Zahir Gorochov, Guy Front Immunol Immunology The capacity of pre-existing immunity to human common coronaviruses (HCoV) to cross-protect against de novo COVID-19is yet unknown. In this work, we studied the sera of 175 COVID-19 patients, 76 healthy donors and 3 intravenous immunoglobulins (IVIG) batches. We found that most COVID-19 patients developed anti-SARS-CoV-2 IgG antibodies before IgM. Moreover, the capacity of their IgGs to react to beta-HCoV, was present in the early sera of most patients before the appearance of anti-SARS-CoV-2 IgG. This implied that a recall-type antibody response was generated. In comparison, the patients that mounted an anti-SARS-COV2 IgM response, prior to IgG responses had lower titres of anti-beta-HCoV IgG antibodies. This indicated that pre-existing immunity to beta-HCoV was conducive to the generation of memory type responses to SARS-COV-2. Finally, we also found that pre-COVID-19-era sera and IVIG cross-reacted with SARS-CoV-2 antigens without neutralising SARS-CoV-2 infectivity in vitro. Put together, these results indicate that whilst pre-existing immunity to HCoV is responsible for recall-type IgG responses to SARS-CoV-2, it does not lead to cross-protection against COVID-19. Frontiers Media S.A. 2022-02-11 /pmc/articles/PMC8873934/ /pubmed/35222375 http://dx.doi.org/10.3389/fimmu.2022.790334 Text en Copyright © 2022 Miyara, Saichi, Sterlin, Anna, Marot, Mathian, Atif, Quentric, Mohr, Claër, Parizot, Dorgham, Yssel, Fadlallah, Chazal, Haroche, Luyt, Mayaux, Beurton, Benameur, Boutolleau, Burrel, de Alba, Mudumba, Hockett, Gunn, Charneau, Calvez, Marcelin, Combes, Demoule, Amoura and Gorochov https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Miyara, Makoto Saichi, Melissa Sterlin, Delphine Anna, François Marot, Stéphane Mathian, Alexis Atif, Mo Quentric, Paul Mohr, Audrey Claër, Laetitia Parizot, Christophe Dorgham, Karim Yssel, Hans Fadlallah, Jehane Chazal, Thibaut Haroche, Julien Luyt, Charles-Edouard Mayaux, Julien Beurton, Alexandra Benameur, Neila Boutolleau, David Burrel, Sonia de Alba, Sophia Mudumba, Sasi Hockett, Rick Gunn, Cary Charneau, Pierre Calvez, Vincent Marcelin, Anne-Geneviève Combes, Alain Demoule, Alexandre Amoura, Zahir Gorochov, Guy Pre-COVID-19 Immunity to Common Cold Human Coronaviruses Induces a Recall-Type IgG Response to SARS-CoV-2 Antigens Without Cross-Neutralisation |
title | Pre-COVID-19 Immunity to Common Cold Human Coronaviruses Induces a Recall-Type IgG Response to SARS-CoV-2 Antigens Without Cross-Neutralisation |
title_full | Pre-COVID-19 Immunity to Common Cold Human Coronaviruses Induces a Recall-Type IgG Response to SARS-CoV-2 Antigens Without Cross-Neutralisation |
title_fullStr | Pre-COVID-19 Immunity to Common Cold Human Coronaviruses Induces a Recall-Type IgG Response to SARS-CoV-2 Antigens Without Cross-Neutralisation |
title_full_unstemmed | Pre-COVID-19 Immunity to Common Cold Human Coronaviruses Induces a Recall-Type IgG Response to SARS-CoV-2 Antigens Without Cross-Neutralisation |
title_short | Pre-COVID-19 Immunity to Common Cold Human Coronaviruses Induces a Recall-Type IgG Response to SARS-CoV-2 Antigens Without Cross-Neutralisation |
title_sort | pre-covid-19 immunity to common cold human coronaviruses induces a recall-type igg response to sars-cov-2 antigens without cross-neutralisation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873934/ https://www.ncbi.nlm.nih.gov/pubmed/35222375 http://dx.doi.org/10.3389/fimmu.2022.790334 |
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