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Cellular origins of regenerating liver and hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the predominant primary cancer arising from the liver and is one of the major causes of cancer-related mortality worldwide. The cellular origin of HCC has been a topic of great interest due to conflicting findings regarding whether it originates in hepatocytes, bili...

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Detalles Bibliográficos
Autores principales: Holczbauer, Ágnes, Wangensteen, Kirk J., Shin, Soona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873941/
https://www.ncbi.nlm.nih.gov/pubmed/35243280
http://dx.doi.org/10.1016/j.jhepr.2021.100416
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author Holczbauer, Ágnes
Wangensteen, Kirk J.
Shin, Soona
author_facet Holczbauer, Ágnes
Wangensteen, Kirk J.
Shin, Soona
author_sort Holczbauer, Ágnes
collection PubMed
description Hepatocellular carcinoma (HCC) is the predominant primary cancer arising from the liver and is one of the major causes of cancer-related mortality worldwide. The cellular origin of HCC has been a topic of great interest due to conflicting findings regarding whether it originates in hepatocytes, biliary cells, or facultative stem cells. These cell types all undergo changes during liver injury, and there is controversy about their contribution to regenerative responses in the liver. Most HCCs emerge in the setting of chronic liver injury from viral hepatitis, fatty liver disease, alcohol, and environmental exposures. The injuries are marked by liver parenchymal changes such as hepatocyte regenerative nodules, biliary duct cellular changes, expansion of myofibroblasts that cause fibrosis and cirrhosis, and inflammatory cell infiltration, all of which may contribute to carcinogenesis. Addressing the cellular origin of HCC is the key to identifying the earliest events that trigger it. Herein, we review data on the cells of origin in regenerating liver and HCC and the implications of these findings for prevention and treatment. We also review the origins of childhood liver cancer and other rare cancers of the liver.
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spelling pubmed-88739412022-03-02 Cellular origins of regenerating liver and hepatocellular carcinoma Holczbauer, Ágnes Wangensteen, Kirk J. Shin, Soona JHEP Rep Review Hepatocellular carcinoma (HCC) is the predominant primary cancer arising from the liver and is one of the major causes of cancer-related mortality worldwide. The cellular origin of HCC has been a topic of great interest due to conflicting findings regarding whether it originates in hepatocytes, biliary cells, or facultative stem cells. These cell types all undergo changes during liver injury, and there is controversy about their contribution to regenerative responses in the liver. Most HCCs emerge in the setting of chronic liver injury from viral hepatitis, fatty liver disease, alcohol, and environmental exposures. The injuries are marked by liver parenchymal changes such as hepatocyte regenerative nodules, biliary duct cellular changes, expansion of myofibroblasts that cause fibrosis and cirrhosis, and inflammatory cell infiltration, all of which may contribute to carcinogenesis. Addressing the cellular origin of HCC is the key to identifying the earliest events that trigger it. Herein, we review data on the cells of origin in regenerating liver and HCC and the implications of these findings for prevention and treatment. We also review the origins of childhood liver cancer and other rare cancers of the liver. Elsevier 2021-12-13 /pmc/articles/PMC8873941/ /pubmed/35243280 http://dx.doi.org/10.1016/j.jhepr.2021.100416 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Holczbauer, Ágnes
Wangensteen, Kirk J.
Shin, Soona
Cellular origins of regenerating liver and hepatocellular carcinoma
title Cellular origins of regenerating liver and hepatocellular carcinoma
title_full Cellular origins of regenerating liver and hepatocellular carcinoma
title_fullStr Cellular origins of regenerating liver and hepatocellular carcinoma
title_full_unstemmed Cellular origins of regenerating liver and hepatocellular carcinoma
title_short Cellular origins of regenerating liver and hepatocellular carcinoma
title_sort cellular origins of regenerating liver and hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873941/
https://www.ncbi.nlm.nih.gov/pubmed/35243280
http://dx.doi.org/10.1016/j.jhepr.2021.100416
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