Cargando…

Cell-Penetrating Botulinum Neurotoxin Type A With Improved Cellular Uptake and Therapeutic Index

Botulinum neurotoxin serotype A (BoNTA) is widely used for treating neuromuscular disorders. Despite of the various marketed products, BoNTA is known to have small therapeutic index ranging from 5 to 15. In the present study, we designed and characterized engineered BoNTA proteins with fusion of cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Xuan, Li, Lu, Wu, Yiwen, Liu, Jia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874009/ https://www.ncbi.nlm.nih.gov/pubmed/35223792 http://dx.doi.org/10.3389/fbioe.2022.828427

Ejemplares similares

Botulinum Neurotoxin Detection Methods for Public Health Response and Surveillance
por: Thirunavukkarasu, Nagarajan, et al.
Publicado: (2018)

Production and characterization of cell-penetrating recombinant botulinum neurotoxin type A
por: Wei, Xuan, et al.
Publicado: (2023)

Influence of Colonies’ Morphological Cues on Cellular Uptake Capacity of Nanoparticles
por: Huang, Siyuan, et al.
Publicado: (2022)

Micro Versus Macro – The Effect of Environmental Confinement on Cellular Nanoparticle Uptake
por: Damle, Viraj G., et al.
Publicado: (2020)

Designing and Characterization of a Novel Delivery System for Improved Cellular Uptake by Brain Using Dendronised Apo-E-Derived Peptide
por: Al-azzawi, Shafq, et al.
Publicado: (2019)

Unlocking cellular barriers: silica nanoparticles and fullerenol conjugated cell-penetrating agents for enhanced intracellular drug delivery
por: Ravelo-Nieto, Eduardo, et al.
Publicado: (2023)

Long-Term Effects With Potential Clinical Importance of Botulinum Toxin Type-A on Mechanics of Muscles Exposed
por: Kaya, Cemre S., et al.
Publicado: (2020)

The Expanding Therapeutic Utility of Botulinum Neurotoxins
por: Fonfria, Elena, et al.
Publicado: (2018)

Dexamethasone-Enhanced Microdialysis and Penetration Injury
por: Jaquins-Gerstl, Andrea, et al.
Publicado: (2020)

Multivalent Chromosomal Expression of the Clostridium botulinum Serotype A Neurotoxin Heavy-Chain Antigen and the Bacillus anthracis Protective Antigen in Lactobacillus acidophilus
por: O'Flaherty, Sarah, et al.
Publicado: (2016)

Mapping the Risk of Fracture of the Tibia From Penetrating Fragments
por: Nguyen, Thuy-Tien N., et al.
Publicado: (2020)

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine
por: Turin, Lauretta, et al.
Publicado: (2023)

On Botulinum Neurotoxin Variability
por: Montecucco, Cesare, et al.
Publicado: (2015)

Patient Perspectives on the Therapeutic Profile of Botulinum Neurotoxin Type A in Spasticity
por: Jacinto, Jorge, et al.
Publicado: (2020)

Characteristics of Harmonic Indexes of the Arterial Blood Pressure Waveform in Type 2 Diabetes Mellitus
por: Liao, Chen-Kai, et al.
Publicado: (2020)

Modulating Alginate Hydrogels for Improved Biological Performance as Cellular 3D Microenvironments
por: Neves, Mariana Isabel, et al.
Publicado: (2020)

Examining the Cellular Transport Pathway of Fusogenic Quantum Dots Conjugated With Tat Peptide
por: Dai, Jie, et al.
Publicado: (2022)

Neurologic uses of botulinum neurotoxin type A
por: Ney, John P, et al.
Publicado: (2007)

Botulinum Neurotoxin Type A in Neurology: Update
por: Orsini, Marco, et al.
Publicado: (2015)

Botulinum Neurotoxins and Botulism: A Novel Therapeutic Approach
por: Thanongsaksrikul, Jeeraphong, et al.
Publicado: (2011)

Therapeutic applications of botulinum neurotoxins in head and neck disorders
por: Alshadwi, Ahmad, et al.
Publicado: (2014)

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review
por: Martina, Emanuela, et al.
Publicado: (2021)

Strategies to improve the therapeutic effect of pluripotent stem cell-derived cardiomyocytes on myocardial infarction
por: Xiao, Yang, et al.
Publicado: (2022)

Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?
por: Poulain, Bernard, et al.
Publicado: (2019)

Nanotheranostics With the Combination of Improved Targeting, Therapeutic Effects, and Molecular Imaging
por: Peng, Shin-Lei, et al.
Publicado: (2020)

Corrigendum: Patient Perspectives on the Therapeutic Profile of Botulinum Neurotoxin Type A in Spasticity
por: Jacinto, Jorge, et al.
Publicado: (2020)

Patient perspectives on the therapeutic profile of botulinum neurotoxin type A in cervical dystonia
por: Comella, Cynthia, et al.
Publicado: (2020)

Changes in the Neural and Non-neural Related Properties of the Spastic Wrist Flexors After Treatment With Botulinum Toxin A in Post-stroke Subjects: An Optimization Study
por: Wang, Ruoli, et al.
Publicado: (2018)

An Integrated Spatial Dynamics—Pharmacokinetic Model Explaining Poor Penetration of Anti-retroviral Drugs in Lymph Nodes
por: Jagarapu, Aditya, et al.
Publicado: (2020)

Zebrafish Sensitivity to Botulinum Neurotoxins
por: Chatla, Kamalakar, et al.
Publicado: (2016)

Use of Botulinum Neurotoxin in Ophthalmology
por: Başar, Emel, et al.
Publicado: (2016)

Antipruritic Effects of Botulinum Neurotoxins
por: Gazerani, Parisa
Publicado: (2018)

Therapy of Sialorrhea with Botulinum Neurotoxin
por: Jost, Wolfgang H., et al.
Publicado: (2019)

Botulinum neurotoxins: Future innovations
por: Brideau-Andersen, Amy, et al.
Publicado: (2023)

Conjugative Botulinum Neurotoxin-Encoding Plasmids in Clostridium botulinum
por: Marshall, Kristin M., et al.
Publicado: (2010)

Comparison of botulinum neurotoxin type A formulations in Asia
por: Frevert, Jürgen, et al.
Publicado: (2018)

Rapid SERS Detection of Botulinum Neurotoxin Type A
por: Subekin, Alexei, et al.
Publicado: (2023)

Action of Botulinum Neurotoxin E Type in Experimental Epilepsies
por: Antonucci, Flavia, et al.
Publicado: (2023)

Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease
por: Le Guellec, Sandrine, et al.
Publicado: (2020)

Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics
por: Davies, Jonathan R., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_m6kr3ea60ouuug0u5spdvoc34o