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Correlation Between Matrix Metalloproteinases With Coronary Artery Lesion Caused by Kawasaki Disease

This study was designed to clarify the role of matrix metalloproteinases (MMPs) in coronary artery lesions (CAL). Serum samples were acquired from healthy, febrile, and Kawasaki disease (KD) children with or without CAL. Standard blood parameters were examined and enzyme-linked immunosorbent assay (...

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Autores principales: Tian, Fang, Ma, Linxi, Zhao, Renbing, Ji, Lijuan, Wang, Xiufen, Sun, Wenli, Jiang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874123/
https://www.ncbi.nlm.nih.gov/pubmed/35223694
http://dx.doi.org/10.3389/fped.2022.802217
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author Tian, Fang
Ma, Linxi
Zhao, Renbing
Ji, Lijuan
Wang, Xiufen
Sun, Wenli
Jiang, Yu
author_facet Tian, Fang
Ma, Linxi
Zhao, Renbing
Ji, Lijuan
Wang, Xiufen
Sun, Wenli
Jiang, Yu
author_sort Tian, Fang
collection PubMed
description This study was designed to clarify the role of matrix metalloproteinases (MMPs) in coronary artery lesions (CAL). Serum samples were acquired from healthy, febrile, and Kawasaki disease (KD) children with or without CAL. Standard blood parameters were examined and enzyme-linked immunosorbent assay (ELISA) was used to assess the levels of MMP-2 and MMP-9. Intravenous immunoglobulin (IVIG) therapy was conducted on the KD patients and the changes of MMPs before and after treatment were compared. The correlations between MMP levels and clinical parameters were also evaluated. Compared to febrile and healthy controls, KD patients demonstrated clinical signs characteristic of abnormal immunoregulation. However, the clinical parameters of KD patients with or without CAL were not significantly different. MMP-2 and MMP-9 levels, however, were significantly higher in KD patients with CAL than those without CAL. IVIG treatment effectively downregulated the levels of MMPs in KD patients, which was more prominent in those with CAL. Significant correlations were found between MMP levels and some clinical parameters of KD, such as fever time, white blood cell count, etc. The upregulation of MMPs significantly correlates with coronary artery aneurysms (CAAs) in KD patients, making it important biomarkers of CAL in KD patients.
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spelling pubmed-88741232022-02-26 Correlation Between Matrix Metalloproteinases With Coronary Artery Lesion Caused by Kawasaki Disease Tian, Fang Ma, Linxi Zhao, Renbing Ji, Lijuan Wang, Xiufen Sun, Wenli Jiang, Yu Front Pediatr Pediatrics This study was designed to clarify the role of matrix metalloproteinases (MMPs) in coronary artery lesions (CAL). Serum samples were acquired from healthy, febrile, and Kawasaki disease (KD) children with or without CAL. Standard blood parameters were examined and enzyme-linked immunosorbent assay (ELISA) was used to assess the levels of MMP-2 and MMP-9. Intravenous immunoglobulin (IVIG) therapy was conducted on the KD patients and the changes of MMPs before and after treatment were compared. The correlations between MMP levels and clinical parameters were also evaluated. Compared to febrile and healthy controls, KD patients demonstrated clinical signs characteristic of abnormal immunoregulation. However, the clinical parameters of KD patients with or without CAL were not significantly different. MMP-2 and MMP-9 levels, however, were significantly higher in KD patients with CAL than those without CAL. IVIG treatment effectively downregulated the levels of MMPs in KD patients, which was more prominent in those with CAL. Significant correlations were found between MMP levels and some clinical parameters of KD, such as fever time, white blood cell count, etc. The upregulation of MMPs significantly correlates with coronary artery aneurysms (CAAs) in KD patients, making it important biomarkers of CAL in KD patients. Frontiers Media S.A. 2022-02-11 /pmc/articles/PMC8874123/ /pubmed/35223694 http://dx.doi.org/10.3389/fped.2022.802217 Text en Copyright © 2022 Tian, Ma, Zhao, Ji, Wang, Sun and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Tian, Fang
Ma, Linxi
Zhao, Renbing
Ji, Lijuan
Wang, Xiufen
Sun, Wenli
Jiang, Yu
Correlation Between Matrix Metalloproteinases With Coronary Artery Lesion Caused by Kawasaki Disease
title Correlation Between Matrix Metalloproteinases With Coronary Artery Lesion Caused by Kawasaki Disease
title_full Correlation Between Matrix Metalloproteinases With Coronary Artery Lesion Caused by Kawasaki Disease
title_fullStr Correlation Between Matrix Metalloproteinases With Coronary Artery Lesion Caused by Kawasaki Disease
title_full_unstemmed Correlation Between Matrix Metalloproteinases With Coronary Artery Lesion Caused by Kawasaki Disease
title_short Correlation Between Matrix Metalloproteinases With Coronary Artery Lesion Caused by Kawasaki Disease
title_sort correlation between matrix metalloproteinases with coronary artery lesion caused by kawasaki disease
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874123/
https://www.ncbi.nlm.nih.gov/pubmed/35223694
http://dx.doi.org/10.3389/fped.2022.802217
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