PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke

There is a critical need for cerebro-protective interventions to improve the suboptimal outcomes of patients with ischemic stroke who have been treated with reperfusion strategies. We found that nuclear pyruvate kinase muscle 2 (PKM2), a modulator of systemic inflammation, was upregulated in neutrop...

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Detalles Bibliográficos
Autores principales: Dhanesha, Nirav, Patel, Rakesh B., Doddapattar, Prakash, Ghatge, Madankumar, Flora, Gagan D., Jain, Manish, Thedens, Daniel, Olalde, Heena, Kumskova, Mariia, Leira, Enrique C., Chauhan, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874361/
https://www.ncbi.nlm.nih.gov/pubmed/34529778
http://dx.doi.org/10.1182/blood.2021012322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874361/
https://www.ncbi.nlm.nih.gov/pubmed/34529778
http://dx.doi.org/10.1182/blood.2021012322

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