Drosophila melanogaster Chemosensory Pathways as Potential Targets to Curb the Insect Menace

SIMPLE SUMMARY: The perception and processing of chemosensory stimuli are indispensable to the survival of living organisms. In insects, olfaction and gustation play a critical role in seeking food, finding mates and avoiding signs of danger. This review aims to present updated information about olfactory and gustatory signaling in the fruit fly Drosophila melanogaster. We have described the mechanisms involved in olfactory and gustatory perceptions at the molecular level, the receptors along with the allied molecules involved, and their signaling pathways in the fruit fly. Due to the magnifying problems of disease-causing insect vectors and crop pests, the applications of chemosensory signaling in controlling pests and insect vectors are also discussed. ABSTRACT: From a unicellular bacterium to a more complex human, smell and taste form an integral part of the basic sensory system. In fruit flies Drosophila melanogaster, the behavioral responses to odorants and tastants are simple, though quite sensitive, and robust. They explain the organization and elementary functioning of the chemosensory system. Molecular and functional analyses of the receptors and other critical molecules involved in olfaction and gustation are not yet completely understood. Hence, a better understanding of chemosensory cue-dependent fruit flies, playing a major role in deciphering the host-seeking behavior of pathogen transmitting insect vectors (mosquitoes, sandflies, ticks) and crop pests (Drosophila suzukii, Queensland fruit fly), is needed. Using D. melanogaster as a model organism, the knowledge gained may be implemented to design new means of controlling insects as well as in analyzing current batches of insect and pest repellents. In this review, the complete mechanisms of olfactory and gustatory perception, along with their implementation in controlling the global threat of disease-transmitting insect vectors and crop-damaging pests, are explained in fruit flies.