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Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control

Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search...

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Autores principales: dos Santos, Guilherme Senna, Miyasato, Patrícia Aoki, Stein, Erika Mattos, Colepicolo, Pio, Wright, Anthony D., Pereira, Carlos Alberto de Bragança, Falkenberg, Miriam, Nakano, Eliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874501/
https://www.ncbi.nlm.nih.gov/pubmed/35200640
http://dx.doi.org/10.3390/md20020111
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author dos Santos, Guilherme Senna
Miyasato, Patrícia Aoki
Stein, Erika Mattos
Colepicolo, Pio
Wright, Anthony D.
Pereira, Carlos Alberto de Bragança
Falkenberg, Miriam
Nakano, Eliana
author_facet dos Santos, Guilherme Senna
Miyasato, Patrícia Aoki
Stein, Erika Mattos
Colepicolo, Pio
Wright, Anthony D.
Pereira, Carlos Alberto de Bragança
Falkenberg, Miriam
Nakano, Eliana
author_sort dos Santos, Guilherme Senna
collection PubMed
description Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species, Laurencia dendroidea, whose extracts demonstrated significant activity toward both Schistosoma mansoni parasites and their intermediate host snails Biomphalaria glabrata. In the present study, three seaweed-derived halogenated sesquiterpenes, (−)-elatol, rogiolol, and obtusol are proposed as potential lead compounds for the development of anthelminthic drugs for the treatment of and pesticides for the environmental control of schistosomiasis. The three compounds were screened for their antischistosomal and molluscicidal activities. The screening revealed that rogiolol exhibits significant activity toward the survival of adult worms, and that all three compounds showed activity against S. mansoni cercariae and B. glabrata embryos. Biomonitored fractioning of L. dendroidea extracts indicated elatol as the most active compound toward cercariae larvae and snail embryos.
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spelling pubmed-88745012022-02-26 Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control dos Santos, Guilherme Senna Miyasato, Patrícia Aoki Stein, Erika Mattos Colepicolo, Pio Wright, Anthony D. Pereira, Carlos Alberto de Bragança Falkenberg, Miriam Nakano, Eliana Mar Drugs Article Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species, Laurencia dendroidea, whose extracts demonstrated significant activity toward both Schistosoma mansoni parasites and their intermediate host snails Biomphalaria glabrata. In the present study, three seaweed-derived halogenated sesquiterpenes, (−)-elatol, rogiolol, and obtusol are proposed as potential lead compounds for the development of anthelminthic drugs for the treatment of and pesticides for the environmental control of schistosomiasis. The three compounds were screened for their antischistosomal and molluscicidal activities. The screening revealed that rogiolol exhibits significant activity toward the survival of adult worms, and that all three compounds showed activity against S. mansoni cercariae and B. glabrata embryos. Biomonitored fractioning of L. dendroidea extracts indicated elatol as the most active compound toward cercariae larvae and snail embryos. MDPI 2022-01-29 /pmc/articles/PMC8874501/ /pubmed/35200640 http://dx.doi.org/10.3390/md20020111 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
dos Santos, Guilherme Senna
Miyasato, Patrícia Aoki
Stein, Erika Mattos
Colepicolo, Pio
Wright, Anthony D.
Pereira, Carlos Alberto de Bragança
Falkenberg, Miriam
Nakano, Eliana
Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control
title Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control
title_full Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control
title_fullStr Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control
title_full_unstemmed Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control
title_short Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control
title_sort algal-derived halogenated sesquiterpenes from laurencia dendroidea as lead compounds in schistosomiasis environmental control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874501/
https://www.ncbi.nlm.nih.gov/pubmed/35200640
http://dx.doi.org/10.3390/md20020111
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