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Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control
Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874501/ https://www.ncbi.nlm.nih.gov/pubmed/35200640 http://dx.doi.org/10.3390/md20020111 |
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author | dos Santos, Guilherme Senna Miyasato, Patrícia Aoki Stein, Erika Mattos Colepicolo, Pio Wright, Anthony D. Pereira, Carlos Alberto de Bragança Falkenberg, Miriam Nakano, Eliana |
author_facet | dos Santos, Guilherme Senna Miyasato, Patrícia Aoki Stein, Erika Mattos Colepicolo, Pio Wright, Anthony D. Pereira, Carlos Alberto de Bragança Falkenberg, Miriam Nakano, Eliana |
author_sort | dos Santos, Guilherme Senna |
collection | PubMed |
description | Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species, Laurencia dendroidea, whose extracts demonstrated significant activity toward both Schistosoma mansoni parasites and their intermediate host snails Biomphalaria glabrata. In the present study, three seaweed-derived halogenated sesquiterpenes, (−)-elatol, rogiolol, and obtusol are proposed as potential lead compounds for the development of anthelminthic drugs for the treatment of and pesticides for the environmental control of schistosomiasis. The three compounds were screened for their antischistosomal and molluscicidal activities. The screening revealed that rogiolol exhibits significant activity toward the survival of adult worms, and that all three compounds showed activity against S. mansoni cercariae and B. glabrata embryos. Biomonitored fractioning of L. dendroidea extracts indicated elatol as the most active compound toward cercariae larvae and snail embryos. |
format | Online Article Text |
id | pubmed-8874501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88745012022-02-26 Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control dos Santos, Guilherme Senna Miyasato, Patrícia Aoki Stein, Erika Mattos Colepicolo, Pio Wright, Anthony D. Pereira, Carlos Alberto de Bragança Falkenberg, Miriam Nakano, Eliana Mar Drugs Article Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species, Laurencia dendroidea, whose extracts demonstrated significant activity toward both Schistosoma mansoni parasites and their intermediate host snails Biomphalaria glabrata. In the present study, three seaweed-derived halogenated sesquiterpenes, (−)-elatol, rogiolol, and obtusol are proposed as potential lead compounds for the development of anthelminthic drugs for the treatment of and pesticides for the environmental control of schistosomiasis. The three compounds were screened for their antischistosomal and molluscicidal activities. The screening revealed that rogiolol exhibits significant activity toward the survival of adult worms, and that all three compounds showed activity against S. mansoni cercariae and B. glabrata embryos. Biomonitored fractioning of L. dendroidea extracts indicated elatol as the most active compound toward cercariae larvae and snail embryos. MDPI 2022-01-29 /pmc/articles/PMC8874501/ /pubmed/35200640 http://dx.doi.org/10.3390/md20020111 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article dos Santos, Guilherme Senna Miyasato, Patrícia Aoki Stein, Erika Mattos Colepicolo, Pio Wright, Anthony D. Pereira, Carlos Alberto de Bragança Falkenberg, Miriam Nakano, Eliana Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control |
title | Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control |
title_full | Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control |
title_fullStr | Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control |
title_full_unstemmed | Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control |
title_short | Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control |
title_sort | algal-derived halogenated sesquiterpenes from laurencia dendroidea as lead compounds in schistosomiasis environmental control |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874501/ https://www.ncbi.nlm.nih.gov/pubmed/35200640 http://dx.doi.org/10.3390/md20020111 |
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