Cargando…

Traditional East Asian Herbal Medicine Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Alzheimer’s disease (AD) is a leading progressive neurodegenerative disease worldwide, and its treatment is a challenging clinical problem. This review was conducted to evaluate the efficacy and safety of herbal medicine for AD treatment. The PubMed, CENTRAL, EMBASE, CNKI, OASIS, KTKP, and CiNii dat...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, JiEun, Kwon, Seungwon, Jin, Chul, Cho, Seung-Yeon, Park, Seong-Uk, Jung, Woo-Sang, Moon, Sang-Kwan, Park, Jung-Mi, Ko, Chang-Nam, Cho, Ki-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874541/
https://www.ncbi.nlm.nih.gov/pubmed/35215287
http://dx.doi.org/10.3390/ph15020174
_version_ 1784657713200889856
author Lee, JiEun
Kwon, Seungwon
Jin, Chul
Cho, Seung-Yeon
Park, Seong-Uk
Jung, Woo-Sang
Moon, Sang-Kwan
Park, Jung-Mi
Ko, Chang-Nam
Cho, Ki-Ho
author_facet Lee, JiEun
Kwon, Seungwon
Jin, Chul
Cho, Seung-Yeon
Park, Seong-Uk
Jung, Woo-Sang
Moon, Sang-Kwan
Park, Jung-Mi
Ko, Chang-Nam
Cho, Ki-Ho
author_sort Lee, JiEun
collection PubMed
description Alzheimer’s disease (AD) is a leading progressive neurodegenerative disease worldwide, and its treatment is a challenging clinical problem. This review was conducted to evaluate the efficacy and safety of herbal medicine for AD treatment. The PubMed, CENTRAL, EMBASE, CNKI, OASIS, KTKP, and CiNii databases were searched until June 2020 for randomized controlled trials (RCTs) on herbal medicine for AD, and a meta-analysis of 57 RCTs was conducted. For cognitive function, herbal medicine significantly improved the Mini-Mental State Examination (MMSE) and AD Assessment Scale-Cognitive Subscale (ADAS-cog) scores compared with conventional medicine. The MMSE scores showed no significant difference between the groups treated with herbal medicine and donepezil; however, herbal medicine significantly lowered the ADAS-cog score. Acori Graminei Rhizoma-containing and Cnidii Rhizoma-containing herbal medicine significantly improved the MMSE and ADAS-cog scores compared with conventional medicine. Ginseng Radix-containing herbal medicine showed a positive, but not statistically significant, tendency toward improving the MMSE score compared with conventional medicine. Herbal medicine with conventional medicine significantly improved the MMSE, ADAS-cog, and Montreal Cognitive Assessment (MoCA) scores compared with conventional medicine, and herbal medicine with donepezil also significantly improved these scores compared with donepezil. Acori Graminei Rhizoma or Cnidii Rhizoma-containing herbal medicine with conventional medicine significantly improved the MMSE and ADAS-cog scores compared with conventional medicine. Ginseng Radix-containing herbal medicine + conventional medicine significantly improved the MMSE score, but not the ADAS-cog score, compared with conventional medicine. For behavioral and psychological symptoms of dementia, the Neuropsychiatry Inventory (NPI) score was not significantly different between herbal and conventional medicines. Herbal medicine with conventional medicine significantly improved the NPI and Behavioral Pathology in Alzheimer’s Disease Rating Scale scores compared with conventional medicine. The NPI score showed no significant difference between the groups treated with herbal medicine and placebo. Furthermore, herbal medicine with conventional medicine significantly lowered plasma amyloid beta levels compared with conventional medicine alone. Herbal medicine, whether used alone or as an adjuvant, may have beneficial effects on AD treatment. However, owing to the methodological limitations and high heterogeneity of the included studies, concrete conclusions cannot be made.
format Online
Article
Text
id pubmed-8874541
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88745412022-02-26 Traditional East Asian Herbal Medicine Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis Lee, JiEun Kwon, Seungwon Jin, Chul Cho, Seung-Yeon Park, Seong-Uk Jung, Woo-Sang Moon, Sang-Kwan Park, Jung-Mi Ko, Chang-Nam Cho, Ki-Ho Pharmaceuticals (Basel) Systematic Review Alzheimer’s disease (AD) is a leading progressive neurodegenerative disease worldwide, and its treatment is a challenging clinical problem. This review was conducted to evaluate the efficacy and safety of herbal medicine for AD treatment. The PubMed, CENTRAL, EMBASE, CNKI, OASIS, KTKP, and CiNii databases were searched until June 2020 for randomized controlled trials (RCTs) on herbal medicine for AD, and a meta-analysis of 57 RCTs was conducted. For cognitive function, herbal medicine significantly improved the Mini-Mental State Examination (MMSE) and AD Assessment Scale-Cognitive Subscale (ADAS-cog) scores compared with conventional medicine. The MMSE scores showed no significant difference between the groups treated with herbal medicine and donepezil; however, herbal medicine significantly lowered the ADAS-cog score. Acori Graminei Rhizoma-containing and Cnidii Rhizoma-containing herbal medicine significantly improved the MMSE and ADAS-cog scores compared with conventional medicine. Ginseng Radix-containing herbal medicine showed a positive, but not statistically significant, tendency toward improving the MMSE score compared with conventional medicine. Herbal medicine with conventional medicine significantly improved the MMSE, ADAS-cog, and Montreal Cognitive Assessment (MoCA) scores compared with conventional medicine, and herbal medicine with donepezil also significantly improved these scores compared with donepezil. Acori Graminei Rhizoma or Cnidii Rhizoma-containing herbal medicine with conventional medicine significantly improved the MMSE and ADAS-cog scores compared with conventional medicine. Ginseng Radix-containing herbal medicine + conventional medicine significantly improved the MMSE score, but not the ADAS-cog score, compared with conventional medicine. For behavioral and psychological symptoms of dementia, the Neuropsychiatry Inventory (NPI) score was not significantly different between herbal and conventional medicines. Herbal medicine with conventional medicine significantly improved the NPI and Behavioral Pathology in Alzheimer’s Disease Rating Scale scores compared with conventional medicine. The NPI score showed no significant difference between the groups treated with herbal medicine and placebo. Furthermore, herbal medicine with conventional medicine significantly lowered plasma amyloid beta levels compared with conventional medicine alone. Herbal medicine, whether used alone or as an adjuvant, may have beneficial effects on AD treatment. However, owing to the methodological limitations and high heterogeneity of the included studies, concrete conclusions cannot be made. MDPI 2022-01-31 /pmc/articles/PMC8874541/ /pubmed/35215287 http://dx.doi.org/10.3390/ph15020174 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Lee, JiEun
Kwon, Seungwon
Jin, Chul
Cho, Seung-Yeon
Park, Seong-Uk
Jung, Woo-Sang
Moon, Sang-Kwan
Park, Jung-Mi
Ko, Chang-Nam
Cho, Ki-Ho
Traditional East Asian Herbal Medicine Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
title Traditional East Asian Herbal Medicine Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
title_full Traditional East Asian Herbal Medicine Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
title_fullStr Traditional East Asian Herbal Medicine Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
title_full_unstemmed Traditional East Asian Herbal Medicine Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
title_short Traditional East Asian Herbal Medicine Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
title_sort traditional east asian herbal medicine treatment for alzheimer’s disease: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874541/
https://www.ncbi.nlm.nih.gov/pubmed/35215287
http://dx.doi.org/10.3390/ph15020174
work_keys_str_mv AT leejieun traditionaleastasianherbalmedicinetreatmentforalzheimersdiseaseasystematicreviewandmetaanalysis
AT kwonseungwon traditionaleastasianherbalmedicinetreatmentforalzheimersdiseaseasystematicreviewandmetaanalysis
AT jinchul traditionaleastasianherbalmedicinetreatmentforalzheimersdiseaseasystematicreviewandmetaanalysis
AT choseungyeon traditionaleastasianherbalmedicinetreatmentforalzheimersdiseaseasystematicreviewandmetaanalysis
AT parkseonguk traditionaleastasianherbalmedicinetreatmentforalzheimersdiseaseasystematicreviewandmetaanalysis
AT jungwoosang traditionaleastasianherbalmedicinetreatmentforalzheimersdiseaseasystematicreviewandmetaanalysis
AT moonsangkwan traditionaleastasianherbalmedicinetreatmentforalzheimersdiseaseasystematicreviewandmetaanalysis
AT parkjungmi traditionaleastasianherbalmedicinetreatmentforalzheimersdiseaseasystematicreviewandmetaanalysis
AT kochangnam traditionaleastasianherbalmedicinetreatmentforalzheimersdiseaseasystematicreviewandmetaanalysis
AT chokiho traditionaleastasianherbalmedicinetreatmentforalzheimersdiseaseasystematicreviewandmetaanalysis