Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies

Francisella is an intracellular, fastidious, Gram-negative bacterium that is difficult to identify using routine microbiological methods in the laboratory. We studied the isolation of Francisella sp. (strain IDAMR664) from the blood of a patient with anti-interferon-γ (IFN-γ) autoantibodies who pres...

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Autores principales: Kajeekul, Rattagan, Insiripong, Somchai, Riwlord, Athita, Poomchuchit, Suleeporn, Kerdsin, Anusak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874608/
https://www.ncbi.nlm.nih.gov/pubmed/35202220
http://dx.doi.org/10.3390/tropicalmed7020025
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author Kajeekul, Rattagan
Insiripong, Somchai
Riwlord, Athita
Poomchuchit, Suleeporn
Kerdsin, Anusak
author_facet Kajeekul, Rattagan
Insiripong, Somchai
Riwlord, Athita
Poomchuchit, Suleeporn
Kerdsin, Anusak
author_sort Kajeekul, Rattagan
collection PubMed
description Francisella is an intracellular, fastidious, Gram-negative bacterium that is difficult to identify using routine microbiological methods in the laboratory. We studied the isolation of Francisella sp. (strain IDAMR664) from the blood of a patient with anti-interferon-γ (IFN-γ) autoantibodies who presented with septicemia and cholestatic hepatitis. Analysis of the strain IDAMR664 genome sequence revealed the isolate was closely related to the strain GA01-2794 that had been isolated from a human in the USA. In addition, it was clustered with F. orientalis, a fish pathogen. The isolate contained several virulence factors and had Francisella pathogenicity island pattern no. 3.
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spelling pubmed-88746082022-02-26 Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies Kajeekul, Rattagan Insiripong, Somchai Riwlord, Athita Poomchuchit, Suleeporn Kerdsin, Anusak Trop Med Infect Dis Article Francisella is an intracellular, fastidious, Gram-negative bacterium that is difficult to identify using routine microbiological methods in the laboratory. We studied the isolation of Francisella sp. (strain IDAMR664) from the blood of a patient with anti-interferon-γ (IFN-γ) autoantibodies who presented with septicemia and cholestatic hepatitis. Analysis of the strain IDAMR664 genome sequence revealed the isolate was closely related to the strain GA01-2794 that had been isolated from a human in the USA. In addition, it was clustered with F. orientalis, a fish pathogen. The isolate contained several virulence factors and had Francisella pathogenicity island pattern no. 3. MDPI 2022-02-11 /pmc/articles/PMC8874608/ /pubmed/35202220 http://dx.doi.org/10.3390/tropicalmed7020025 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kajeekul, Rattagan
Insiripong, Somchai
Riwlord, Athita
Poomchuchit, Suleeporn
Kerdsin, Anusak
Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies
title Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies
title_full Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies
title_fullStr Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies
title_full_unstemmed Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies
title_short Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies
title_sort francisella sp., a close relative of francisella orientalis, causing septicemia with cholestatic hepatitis in a patient with anti-interferon-γ (ifn-γ) autoantibodies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874608/
https://www.ncbi.nlm.nih.gov/pubmed/35202220
http://dx.doi.org/10.3390/tropicalmed7020025
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