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Distinct Outcomes in COVID-19 Patients with Positive or Negative RT-PCR Test

Identification of the SARS-CoV-2 virus by RT-PCR from a nasopharyngeal swab sample is a common test for diagnosing COVID-19. However, some patients present clinical, laboratorial, and radiological evidence of COVID-19 infection with negative RT-PCR result(s). Thus, we assessed whether positive resul...

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Detalles Bibliográficos
Autores principales: Saad Menezes, Maria Clara, Santinelli Pestana, Diego Vinicius, Ferreira, Juliana Carvalho, Ribeiro de Carvalho, Carlos Roberto, Felix, Marcelo Consorti, Marcilio, Izabel Oliva, da Silva, Katia Regina, Junior, Vilson Cobello, Marchini, Julio Flavio, Alencar, Julio Cesar, Gomez, Luz Marina Gomez, Mauá, Denis Deratani, Souza, Heraldo Possolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874612/
https://www.ncbi.nlm.nih.gov/pubmed/35215772
http://dx.doi.org/10.3390/v14020175
Descripción
Sumario:Identification of the SARS-CoV-2 virus by RT-PCR from a nasopharyngeal swab sample is a common test for diagnosing COVID-19. However, some patients present clinical, laboratorial, and radiological evidence of COVID-19 infection with negative RT-PCR result(s). Thus, we assessed whether positive results were associated with intubation and mortality. This study was conducted in a Brazilian tertiary hospital from March to August of 2020. All patients had clinical, laboratory, and radiological diagnosis of COVID-19. They were divided into two groups: positive (+) RT-PCR group, with 2292 participants, and negative (−) RT-PCR group, with 706 participants. Patients with negative RT-PCR testing and an alternative most probable diagnosis were excluded from the study. The RT-PCR(+) group presented increased risk of intensive care unit (ICU) admission, mechanical ventilation, length of hospital stay, and 28-day mortality, when compared to the RT-PCR(−) group. A positive SARS-CoV-2 RT-PCR result was independently associated with intubation and 28 day in-hospital mortality. Accordingly, we concluded that patients with a COVID-19 diagnosis based on clinical data, despite a negative RT-PCR test from nasopharyngeal samples, presented more favorable outcomes than patients with positive RT-PCR test(s).