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Distinct Outcomes in COVID-19 Patients with Positive or Negative RT-PCR Test

Identification of the SARS-CoV-2 virus by RT-PCR from a nasopharyngeal swab sample is a common test for diagnosing COVID-19. However, some patients present clinical, laboratorial, and radiological evidence of COVID-19 infection with negative RT-PCR result(s). Thus, we assessed whether positive resul...

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Autores principales: Saad Menezes, Maria Clara, Santinelli Pestana, Diego Vinicius, Ferreira, Juliana Carvalho, Ribeiro de Carvalho, Carlos Roberto, Felix, Marcelo Consorti, Marcilio, Izabel Oliva, da Silva, Katia Regina, Junior, Vilson Cobello, Marchini, Julio Flavio, Alencar, Julio Cesar, Gomez, Luz Marina Gomez, Mauá, Denis Deratani, Souza, Heraldo Possolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874612/
https://www.ncbi.nlm.nih.gov/pubmed/35215772
http://dx.doi.org/10.3390/v14020175
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author Saad Menezes, Maria Clara
Santinelli Pestana, Diego Vinicius
Ferreira, Juliana Carvalho
Ribeiro de Carvalho, Carlos Roberto
Felix, Marcelo Consorti
Marcilio, Izabel Oliva
da Silva, Katia Regina
Junior, Vilson Cobello
Marchini, Julio Flavio
Alencar, Julio Cesar
Gomez, Luz Marina Gomez
Mauá, Denis Deratani
Souza, Heraldo Possolo
author_facet Saad Menezes, Maria Clara
Santinelli Pestana, Diego Vinicius
Ferreira, Juliana Carvalho
Ribeiro de Carvalho, Carlos Roberto
Felix, Marcelo Consorti
Marcilio, Izabel Oliva
da Silva, Katia Regina
Junior, Vilson Cobello
Marchini, Julio Flavio
Alencar, Julio Cesar
Gomez, Luz Marina Gomez
Mauá, Denis Deratani
Souza, Heraldo Possolo
author_sort Saad Menezes, Maria Clara
collection PubMed
description Identification of the SARS-CoV-2 virus by RT-PCR from a nasopharyngeal swab sample is a common test for diagnosing COVID-19. However, some patients present clinical, laboratorial, and radiological evidence of COVID-19 infection with negative RT-PCR result(s). Thus, we assessed whether positive results were associated with intubation and mortality. This study was conducted in a Brazilian tertiary hospital from March to August of 2020. All patients had clinical, laboratory, and radiological diagnosis of COVID-19. They were divided into two groups: positive (+) RT-PCR group, with 2292 participants, and negative (−) RT-PCR group, with 706 participants. Patients with negative RT-PCR testing and an alternative most probable diagnosis were excluded from the study. The RT-PCR(+) group presented increased risk of intensive care unit (ICU) admission, mechanical ventilation, length of hospital stay, and 28-day mortality, when compared to the RT-PCR(−) group. A positive SARS-CoV-2 RT-PCR result was independently associated with intubation and 28 day in-hospital mortality. Accordingly, we concluded that patients with a COVID-19 diagnosis based on clinical data, despite a negative RT-PCR test from nasopharyngeal samples, presented more favorable outcomes than patients with positive RT-PCR test(s).
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spelling pubmed-88746122022-02-26 Distinct Outcomes in COVID-19 Patients with Positive or Negative RT-PCR Test Saad Menezes, Maria Clara Santinelli Pestana, Diego Vinicius Ferreira, Juliana Carvalho Ribeiro de Carvalho, Carlos Roberto Felix, Marcelo Consorti Marcilio, Izabel Oliva da Silva, Katia Regina Junior, Vilson Cobello Marchini, Julio Flavio Alencar, Julio Cesar Gomez, Luz Marina Gomez Mauá, Denis Deratani Souza, Heraldo Possolo Viruses Article Identification of the SARS-CoV-2 virus by RT-PCR from a nasopharyngeal swab sample is a common test for diagnosing COVID-19. However, some patients present clinical, laboratorial, and radiological evidence of COVID-19 infection with negative RT-PCR result(s). Thus, we assessed whether positive results were associated with intubation and mortality. This study was conducted in a Brazilian tertiary hospital from March to August of 2020. All patients had clinical, laboratory, and radiological diagnosis of COVID-19. They were divided into two groups: positive (+) RT-PCR group, with 2292 participants, and negative (−) RT-PCR group, with 706 participants. Patients with negative RT-PCR testing and an alternative most probable diagnosis were excluded from the study. The RT-PCR(+) group presented increased risk of intensive care unit (ICU) admission, mechanical ventilation, length of hospital stay, and 28-day mortality, when compared to the RT-PCR(−) group. A positive SARS-CoV-2 RT-PCR result was independently associated with intubation and 28 day in-hospital mortality. Accordingly, we concluded that patients with a COVID-19 diagnosis based on clinical data, despite a negative RT-PCR test from nasopharyngeal samples, presented more favorable outcomes than patients with positive RT-PCR test(s). MDPI 2022-01-18 /pmc/articles/PMC8874612/ /pubmed/35215772 http://dx.doi.org/10.3390/v14020175 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Saad Menezes, Maria Clara
Santinelli Pestana, Diego Vinicius
Ferreira, Juliana Carvalho
Ribeiro de Carvalho, Carlos Roberto
Felix, Marcelo Consorti
Marcilio, Izabel Oliva
da Silva, Katia Regina
Junior, Vilson Cobello
Marchini, Julio Flavio
Alencar, Julio Cesar
Gomez, Luz Marina Gomez
Mauá, Denis Deratani
Souza, Heraldo Possolo
Distinct Outcomes in COVID-19 Patients with Positive or Negative RT-PCR Test
title Distinct Outcomes in COVID-19 Patients with Positive or Negative RT-PCR Test
title_full Distinct Outcomes in COVID-19 Patients with Positive or Negative RT-PCR Test
title_fullStr Distinct Outcomes in COVID-19 Patients with Positive or Negative RT-PCR Test
title_full_unstemmed Distinct Outcomes in COVID-19 Patients with Positive or Negative RT-PCR Test
title_short Distinct Outcomes in COVID-19 Patients with Positive or Negative RT-PCR Test
title_sort distinct outcomes in covid-19 patients with positive or negative rt-pcr test
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874612/
https://www.ncbi.nlm.nih.gov/pubmed/35215772
http://dx.doi.org/10.3390/v14020175
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